Effects of Ferrofluid and Phytoalexin Spirobrassinin on Thioflavin-T-Based Fluorescence in Cerebrospinal Fluid of the Elderly and Multiple Sclerosis Patients
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908864" target="_blank" >RIV/00216208:11120/14:43908864 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023752:_____/14:43914592
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s11064-014-1340-0" target="_blank" >http://dx.doi.org/10.1007/s11064-014-1340-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11064-014-1340-0" target="_blank" >10.1007/s11064-014-1340-0</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effects of Ferrofluid and Phytoalexin Spirobrassinin on Thioflavin-T-Based Fluorescence in Cerebrospinal Fluid of the Elderly and Multiple Sclerosis Patients
Popis výsledku v původním jazyce
It is well known that misfolded peptides/proteins can play a role in processes of normal ageing and in the pathogenesis of many diseases including Alzheimer's disease. Previously, we evaluated samples of cerebrospinal fluid from patients with Alzheimer'sdisease and multiple sclerosis by means of thioflavin-T-based fluorescence. We observed attenuated effects of magnetite nanoparticles operated via anti-aggregation actions on peptides/proteins from patients with Alzheimer's disease but not from those with multiple sclerosis when compared to age-related controls. In this study, we have evaluated the in vitro effects of anti-aggregation operating ferrofluid and phytoalexin spirobrassinin in the cerebrospinal fluid of patients with multiple sclerosis andAlzheimer's disease. We have found significant differences in native fluorescence (lambda excitation = 440 nm, lambda emission = 485 nm) of samples among particular groups (young controls < multiple sclerosis, Alzheimer's disease < old co
Název v anglickém jazyce
Effects of Ferrofluid and Phytoalexin Spirobrassinin on Thioflavin-T-Based Fluorescence in Cerebrospinal Fluid of the Elderly and Multiple Sclerosis Patients
Popis výsledku anglicky
It is well known that misfolded peptides/proteins can play a role in processes of normal ageing and in the pathogenesis of many diseases including Alzheimer's disease. Previously, we evaluated samples of cerebrospinal fluid from patients with Alzheimer'sdisease and multiple sclerosis by means of thioflavin-T-based fluorescence. We observed attenuated effects of magnetite nanoparticles operated via anti-aggregation actions on peptides/proteins from patients with Alzheimer's disease but not from those with multiple sclerosis when compared to age-related controls. In this study, we have evaluated the in vitro effects of anti-aggregation operating ferrofluid and phytoalexin spirobrassinin in the cerebrospinal fluid of patients with multiple sclerosis andAlzheimer's disease. We have found significant differences in native fluorescence (lambda excitation = 440 nm, lambda emission = 485 nm) of samples among particular groups (young controls < multiple sclerosis, Alzheimer's disease < old co
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neurochemical Research
ISSN
0364-3190
e-ISSN
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Svazek periodika
39
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
1502-1510
Kód UT WoS článku
000340401200013
EID výsledku v databázi Scopus
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