Analysis of the Phenotype and Function of the Subpopulations of Mucosal-Associated Invariant T Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000120" target="_blank" >RIV/00064173:_____/16:N0000120 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/16:43912046

Výsledek na webu

<a href="http://dx.doi.org/10.1111/sji.12467" target="_blank" >http://dx.doi.org/10.1111/sji.12467</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sji.12467" target="_blank" >10.1111/sji.12467</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of the Phenotype and Function of the Subpopulations of Mucosal-Associated Invariant T Cells

Popis výsledku v původním jazyce

Mucosal-associated invariant T (MAIT) cells contain two main subpopulations, CD8+ and double negative (DN) cells. The first reports suggested that subpopulations of MAIT cells have similar phenotype and function. Recent works, however, demonstrate that the subpopulations have different ontogenesis and are differentially affected by xenobiotic treatment. In this work we reexamined the possible differences between subpopulations of MAIT cells. We demonstrate that the main subpopulations of MAIT cells (CD8 and DN) are relatively uniform both in terms of phenotype and function. Both populations are memory/activated, tissue homing, and pro-inflammatory. CD8+ MAIT cells are better equipped for pro-inflammatory functions as they express higher levels of CD16 and NKG2D, produce more pro-inflammatory cytokines (TNF-α and IFN-γ), and have higher cytotoxic potential (contain more Granzyme B and express higher levels of CD107A upon stimulation). Our study contributes to the understanding of the heterogenity of MAIT cell population.

Název v anglickém jazyce

Analysis of the Phenotype and Function of the Subpopulations of Mucosal-Associated Invariant T Cells

Popis výsledku anglicky

Mucosal-associated invariant T (MAIT) cells contain two main subpopulations, CD8+ and double negative (DN) cells. The first reports suggested that subpopulations of MAIT cells have similar phenotype and function. Recent works, however, demonstrate that the subpopulations have different ontogenesis and are differentially affected by xenobiotic treatment. In this work we reexamined the possible differences between subpopulations of MAIT cells. We demonstrate that the main subpopulations of MAIT cells (CD8 and DN) are relatively uniform both in terms of phenotype and function. Both populations are memory/activated, tissue homing, and pro-inflammatory. CD8+ MAIT cells are better equipped for pro-inflammatory functions as they express higher levels of CD16 and NKG2D, produce more pro-inflammatory cytokines (TNF-α and IFN-γ), and have higher cytotoxic potential (contain more Granzyme B and express higher levels of CD107A upon stimulation). Our study contributes to the understanding of the heterogenity of MAIT cell population.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scandinavian Journal of Immunology

ISSN

0300-9475

e-ISSN

—

Svazek periodika

84

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

245-251

Kód UT WoS článku

000387048700007

EID výsledku v databázi Scopus

2-s2.0-84988632601