Nephrogenic systemic fibrosis: the end of the story?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F19%3AN0000170" target="_blank" >RIV/00064173:_____/19:N0000170 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.21037/qims.2019.07.11" target="_blank" >https://doi.org/10.21037/qims.2019.07.11</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21037/qims.2019.07.11" target="_blank" >10.21037/qims.2019.07.11</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nephrogenic systemic fibrosis: the end of the story?

Popis výsledku v původním jazyce

Gadolinium-based contrast agents (GBCA) have been standardly intravenously applied to improve visibility of MRI examinations since 1988, when gadopentetate dimeglumine (Magnevist(R)) was approved for clinical practice. Gadolinium itself is a heavy metal, highly toxic in biological systems. Therefore, gadolinium must be bound to ligands for the purpose of contrast agents. GBCA consist of gadolinium ion and a chelating molecule, which could be cyclic or linear. The macrocyclic molecule pre-organizes the rigid ring to cage the gadolinium ion, which offers better protection and binding of gadolinium ion. Linear chelates with a flexible open chain are less stable and provide weaker link of the gadolinium ion. The rate of gadolinium dissociation from the macrocyclic ligands is remarkably slower than their dissociation from the linear chelates.

Název v anglickém jazyce

Nephrogenic systemic fibrosis: the end of the story?

Popis výsledku anglicky

Gadolinium-based contrast agents (GBCA) have been standardly intravenously applied to improve visibility of MRI examinations since 1988, when gadopentetate dimeglumine (Magnevist(R)) was approved for clinical practice. Gadolinium itself is a heavy metal, highly toxic in biological systems. Therefore, gadolinium must be bound to ligands for the purpose of contrast agents. GBCA consist of gadolinium ion and a chelating molecule, which could be cyclic or linear. The macrocyclic molecule pre-organizes the rigid ring to cage the gadolinium ion, which offers better protection and binding of gadolinium ion. Linear chelates with a flexible open chain are less stable and provide weaker link of the gadolinium ion. The rate of gadolinium dissociation from the macrocyclic ligands is remarkably slower than their dissociation from the linear chelates.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Quantitative Imaging in Medicine and Surgery

ISSN

2223-4292

e-ISSN

2223-4306

Svazek periodika

9

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

5

Strana od-do

1470-1474

Kód UT WoS článku

000483402700013

EID výsledku v databázi Scopus

2-s2.0-85075988439