Gadolinium contrast agents - are they really safe?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913120" target="_blank" >RIV/00216208:11120/17:43913120 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/17:10359061 RIV/00064173:_____/17:N0000038

Výsledek na webu

<a href="http://dx.doi.org/10.5301/jva.5000713" target="_blank" >http://dx.doi.org/10.5301/jva.5000713</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5301/jva.5000713" target="_blank" >10.5301/jva.5000713</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gadolinium contrast agents - are they really safe?

Popis výsledku v původním jazyce

Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be easier released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease.Two states are related to gadolinium: nephrogenic systemic fibrosis (NSF) and gadolinium body storage. NSF is a severe and debilitating disease, directly connected to gadolinium toxicity, proven after the use of linear chelates. Due to strict recommendations of radiology societies, NSF was practically eradicated. Gadolinium deposition was observed especially in bones and in some brain areas: in dentate nucleus and in globus pallidus, even years after the GBCA administration. The form of the storage (chelated or free), as well as their clinical impact, are not clear, but first observations of &quot;gadolinium deposition disease&quot; have been reported.

Název v anglickém jazyce

Gadolinium contrast agents - are they really safe?

Popis výsledku anglicky

Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be easier released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease.Two states are related to gadolinium: nephrogenic systemic fibrosis (NSF) and gadolinium body storage. NSF is a severe and debilitating disease, directly connected to gadolinium toxicity, proven after the use of linear chelates. Due to strict recommendations of radiology societies, NSF was practically eradicated. Gadolinium deposition was observed especially in bones and in some brain areas: in dentate nucleus and in globus pallidus, even years after the GBCA administration. The form of the storage (chelated or free), as well as their clinical impact, are not clear, but first observations of &quot;gadolinium deposition disease&quot; have been reported.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Vascular Access

ISSN

1129-7298

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

Suppl. 2

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

7

Strana od-do

"S1"-"S7"

Kód UT WoS článku

000399094300001

EID výsledku v databázi Scopus

2-s2.0-85019036925