Nephrogenic systemic fibrosis: the end of the story?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F19%3A43918735" target="_blank" >RIV/00216208:11120/19:43918735 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.21037/qims.2019.07.11" target="_blank" >https://doi.org/10.21037/qims.2019.07.11</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21037/qims.2019.07.11" target="_blank" >10.21037/qims.2019.07.11</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Nephrogenic systemic fibrosis: the end of the story?
Popis výsledku v původním jazyce
Gadolinium-based contrast agents (GBCA) have been standardly intravenously applied to improve visibility of MRI examinations since 1988, when gadopentetate dimeglumine (Magnevist(R)) was approved for clinical practice. Gadolinium itself is a heavy metal, highly toxic in biological systems. Therefore, gadolinium must be bound to ligands for the purpose of contrast agents. GBCA consist of gadolinium ion and a chelating molecule, which could be cyclic or linear. The macrocyclic molecule pre-organizes the rigid ring to cage the gadolinium ion, which offers better protection and binding of gadolinium ion. Linear chelates with a flexible open chain are less stable and provide weaker link of the gadolinium ion. The rate of gadolinium dissociation from the macrocyclic ligands is remarkably slower than their dissociation from the linear chelates
Název v anglickém jazyce
Nephrogenic systemic fibrosis: the end of the story?
Popis výsledku anglicky
Gadolinium-based contrast agents (GBCA) have been standardly intravenously applied to improve visibility of MRI examinations since 1988, when gadopentetate dimeglumine (Magnevist(R)) was approved for clinical practice. Gadolinium itself is a heavy metal, highly toxic in biological systems. Therefore, gadolinium must be bound to ligands for the purpose of contrast agents. GBCA consist of gadolinium ion and a chelating molecule, which could be cyclic or linear. The macrocyclic molecule pre-organizes the rigid ring to cage the gadolinium ion, which offers better protection and binding of gadolinium ion. Linear chelates with a flexible open chain are less stable and provide weaker link of the gadolinium ion. The rate of gadolinium dissociation from the macrocyclic ligands is remarkably slower than their dissociation from the linear chelates
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30224 - Radiology, nuclear medicine and medical imaging
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů