Correlation of MRI- evaluated degenerative disc disease with positivity on Single-Photon Emission Computed Tomography Imaging in patients with chronic low back pain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43927423" target="_blank" >RIV/00064173:_____/24:43927423 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/24:00001401 RIV/00216208:11110/24:10482326 RIV/00216208:11120/24:43927423 RIV/00064203:_____/24:10482326

Výsledek na webu

<a href="https://doi.org/10.1016/j.wneu.2024.07.163" target="_blank" >https://doi.org/10.1016/j.wneu.2024.07.163</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.wneu.2024.07.163" target="_blank" >10.1016/j.wneu.2024.07.163</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Correlation of MRI- evaluated degenerative disc disease with positivity on Single-Photon Emission Computed Tomography Imaging in patients with chronic low back pain

Popis výsledku v původním jazyce

PURPOSE: Chronic low back pain (CLBP), affecting up to 58% of the population, often stems from intervertebral disc degeneration. Although magnetic resonance imaging (MRI) is commonly used for diagnostics, challenges arise in pinpointing pain sources due to frequent asymptomatic findings. Single-photon emission tomography (SPECT) integrated with computed tomography (CT) offers a promising approach, enhancing sensitivity and specificity. METHODS: In this retrospective study, spanning 2016 to 2022, SPECT/CT imaging was performed on 193 patients meeting specific criteria. We correlated SPECT/CT findings with lumbar MRI results, utilizing Pfirrmann and Rajasekaran classifications for disc degeneration and endplate damage assessment. Logistic regression analysis adjusted for age and sex evaluated associations. RESULTS: Of 965 spinal levels assessed, SPECT/CT positivity strongly correlated with higher Pfirrmann grades and Rajasekaran endplate classifications. Notably, Modic changes on MRI displayed a non-significant relationship with SPECT/CT positivity. Significant associations were observed in older patients with positive Modic changes, Pfirrmann grades, and Rajasekaran classifications. CONCLUSION: This comprehensive study, the largest of its kind, establishes a significant link between SPECT/CT positivity and advanced lumbar degenerative changes. Higher Pfirrmann grades and increased Rajasekaran endplate damage demonstrated substantial correlations with SPECT/CT positivity. Notably, Modic changes did not exhibit such association. Our findings underscore the potential of SPECT/CT in identifying pain generators in degenerative spinal conditions, offering valuable insights for future interventions.

Název v anglickém jazyce

Correlation of MRI- evaluated degenerative disc disease with positivity on Single-Photon Emission Computed Tomography Imaging in patients with chronic low back pain

Popis výsledku anglicky

PURPOSE: Chronic low back pain (CLBP), affecting up to 58% of the population, often stems from intervertebral disc degeneration. Although magnetic resonance imaging (MRI) is commonly used for diagnostics, challenges arise in pinpointing pain sources due to frequent asymptomatic findings. Single-photon emission tomography (SPECT) integrated with computed tomography (CT) offers a promising approach, enhancing sensitivity and specificity. METHODS: In this retrospective study, spanning 2016 to 2022, SPECT/CT imaging was performed on 193 patients meeting specific criteria. We correlated SPECT/CT findings with lumbar MRI results, utilizing Pfirrmann and Rajasekaran classifications for disc degeneration and endplate damage assessment. Logistic regression analysis adjusted for age and sex evaluated associations. RESULTS: Of 965 spinal levels assessed, SPECT/CT positivity strongly correlated with higher Pfirrmann grades and Rajasekaran endplate classifications. Notably, Modic changes on MRI displayed a non-significant relationship with SPECT/CT positivity. Significant associations were observed in older patients with positive Modic changes, Pfirrmann grades, and Rajasekaran classifications. CONCLUSION: This comprehensive study, the largest of its kind, establishes a significant link between SPECT/CT positivity and advanced lumbar degenerative changes. Higher Pfirrmann grades and increased Rajasekaran endplate damage demonstrated substantial correlations with SPECT/CT positivity. Notably, Modic changes did not exhibit such association. Our findings underscore the potential of SPECT/CT in identifying pain generators in degenerative spinal conditions, offering valuable insights for future interventions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

World Neurosurgery

ISSN

1878-8750

e-ISSN

1878-8769

Svazek periodika

190

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

"e504"-"e512"

Kód UT WoS článku

001338768900001

EID výsledku v databázi Scopus

2-s2.0-85202214125