Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F10%3A%230000025" target="_blank" >RIV/00064190:_____/10:#0000025 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance.

Popis výsledku v původním jazyce

The aim of the study was to analyze menopausal changes in components of metabolic syndrome (MS) and the parameter of insulin resistance (HOMA-IR). A random population sample of 909 women aged 45?54 years was examined. RESULTS The prevalence of MS rose significantly in menopause (REPRO/POSTm 22.9+2.6% /38.3+4.0%; p<0.001). However, a detailed analysis showed among the five components defining MS that increases were only seen in waist circumference (p<0.0001) and triglycerides (p<0.001). A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, ns; high HOMA-IR 1.8/2.1, p<0.001) and an increase in the prevalence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm:low HOMAIR 13.8%/18.7%, ns; high HOMA-IR 30.9%/57.3%, p<0.0001). CONCLUSION The acceleration of MS prevalence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk.

Název v anglickém jazyce

Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance.

Popis výsledku anglicky

The aim of the study was to analyze menopausal changes in components of metabolic syndrome (MS) and the parameter of insulin resistance (HOMA-IR). A random population sample of 909 women aged 45?54 years was examined. RESULTS The prevalence of MS rose significantly in menopause (REPRO/POSTm 22.9+2.6% /38.3+4.0%; p<0.001). However, a detailed analysis showed among the five components defining MS that increases were only seen in waist circumference (p<0.0001) and triglycerides (p<0.001). A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, ns; high HOMA-IR 1.8/2.1, p<0.001) and an increase in the prevalence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm:low HOMAIR 13.8%/18.7%, ns; high HOMA-IR 30.9%/57.3%, p<0.0001). CONCLUSION The acceleration of MS prevalence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Climacteric

ISSN

1369-7137

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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