Short-course whole-brain radiotherapy (WBRT) for brain metastases due to small-cell lung cancer (SCLC)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A10294187" target="_blank" >RIV/00064203:_____/10:10294187 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/10:10294187

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clineuro.2009.11.004" target="_blank" >http://dx.doi.org/10.1016/j.clineuro.2009.11.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clineuro.2009.11.004" target="_blank" >10.1016/j.clineuro.2009.11.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Short-course whole-brain radiotherapy (WBRT) for brain metastases due to small-cell lung cancer (SCLC)

Popis výsledku v původním jazyce

Objective: Many patients with brain metastases due to SCLC have a poor survival prognosis. The most common treatment is whole-brain radiotherapy (WBRT). This retrospective study compares short-course WBRT with 5 x 4 Gy in 1 week to standard WBRT with 10x 3 Gy in 2 weeks. Methods: Forty-four SCLC patients receiving WBRT with 5 x 4 Gy were compared to 102 patients receiving 10 x 3 Gy for survival (OS) and local (intracerebral) control (LC). Seven further potential prognostic factors were investigated: age, gender, Karnofsky Performance Score (KPS), number of brain metastases, extracerebral metastases, interval from tumor diagnosis to WBRT, RPA (Recursive Partitioning Analysis) class. Results: After 5 x 4 Gy, 12-month OS was 15%, versus 22% after 10 x 3Gy (p = 0.69). On multivariate analysis, improved OS was associated with age {= 60 years (p = 0.013), KPS }= 70 (p < 0.001). <4 brain metastases (p = 0.011), and RPA class 1 (p < 0.001). 12-month LC was 34% after 5 x 4 Gy versus 25% after

Název v anglickém jazyce

Short-course whole-brain radiotherapy (WBRT) for brain metastases due to small-cell lung cancer (SCLC)

Popis výsledku anglicky

Objective: Many patients with brain metastases due to SCLC have a poor survival prognosis. The most common treatment is whole-brain radiotherapy (WBRT). This retrospective study compares short-course WBRT with 5 x 4 Gy in 1 week to standard WBRT with 10x 3 Gy in 2 weeks. Methods: Forty-four SCLC patients receiving WBRT with 5 x 4 Gy were compared to 102 patients receiving 10 x 3 Gy for survival (OS) and local (intracerebral) control (LC). Seven further potential prognostic factors were investigated: age, gender, Karnofsky Performance Score (KPS), number of brain metastases, extracerebral metastases, interval from tumor diagnosis to WBRT, RPA (Recursive Partitioning Analysis) class. Results: After 5 x 4 Gy, 12-month OS was 15%, versus 22% after 10 x 3Gy (p = 0.69). On multivariate analysis, improved OS was associated with age {= 60 years (p = 0.013), KPS }= 70 (p < 0.001). <4 brain metastases (p = 0.011), and RPA class 1 (p < 0.001). 12-month LC was 34% after 5 x 4 Gy versus 25% after

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurology and Neurosurgery

ISSN

0303-8467

e-ISSN

—

Svazek periodika

112

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

183-187

Kód UT WoS článku

000276049900002

EID výsledku v databázi Scopus

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