Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A10294185" target="_blank" >RIV/00064203:_____/11:10294185 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/11:10294185

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijrobp.2011.01.058" target="_blank" >http://dx.doi.org/10.1016/j.ijrobp.2011.01.058</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijrobp.2011.01.058" target="_blank" >10.1016/j.ijrobp.2011.01.058</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients

Popis výsledku v původním jazyce

Purpose: Many patients with brain metastases receive whole-brain radiotherapy (WBRT) alone. Using 10 x 3 Gy in 2 weeks is the standard regimen in most centers. Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brainmetastases, a shorter WBRT regimen would be preferable. This study compared 10 x 3 Gy with 5 x 4 Gy in elderly patients (}= 65 years). Methods and Materials: Data from 455 elderly patients who received WBRT alone for brain metastases were retrospectivelyanalyzed. Survival and local (= intracerebral) control of 293 patients receiving 10 x 3 Gy were compared with 162 patients receiving 5 x 4 Gy. Eight additional potential prognostic factors were investigated including age, gender, Karnofsky performance score (KPS), primary tumor, number of brain metastases, interval from tumor diagnosis to WBRT, extracerebral metastases, and recursive partitioning analysis (RPA) class. Results: The 6-month overall survival rates were 29% after 5 x 4 Gy a

Název v anglickém jazyce

Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients

Popis výsledku anglicky

Purpose: Many patients with brain metastases receive whole-brain radiotherapy (WBRT) alone. Using 10 x 3 Gy in 2 weeks is the standard regimen in most centers. Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brainmetastases, a shorter WBRT regimen would be preferable. This study compared 10 x 3 Gy with 5 x 4 Gy in elderly patients (}= 65 years). Methods and Materials: Data from 455 elderly patients who received WBRT alone for brain metastases were retrospectivelyanalyzed. Survival and local (= intracerebral) control of 293 patients receiving 10 x 3 Gy were compared with 162 patients receiving 5 x 4 Gy. Eight additional potential prognostic factors were investigated including age, gender, Karnofsky performance score (KPS), primary tumor, number of brain metastases, interval from tumor diagnosis to WBRT, extracerebral metastases, and recursive partitioning analysis (RPA) class. Results: The 6-month overall survival rates were 29% after 5 x 4 Gy a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Radiation Oncology Biology Physics

ISSN

0360-3016

e-ISSN

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Svazek periodika

81

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

"E469"-"E473"

Kód UT WoS článku

000309412300035

EID výsledku v databázi Scopus

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