Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A10294184" target="_blank" >RIV/00064203:_____/12:10294184 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/12:10294184
Výsledek na webu
<a href="http://dx.doi.org/10.1002/cncr.26680" target="_blank" >http://dx.doi.org/10.1002/cncr.26680</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cncr.26680" target="_blank" >10.1002/cncr.26680</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
Popis výsledku v původním jazyce
BACKGROUND: Patients with brain metastases who have a favorable survival prognosis may benefit from intensive treatments, including neurosurgery and radiosurgery. However, many patients cannot receive such treatments, and whole-brain radiotherapy (WBRT)alone is their only option. The most common WBRT schedule is 30 grays (Gy) in 10 fractions. In this retrospective study, the authors investigated whether these patients benefit from a dose escalation beyond 30 Gy. METHODS: Data from 109 patients who received 30 Gy in 10 fractions were compared with 75 patients who received 40 Gy in 20 fractions. All patients had a favorable survival prognosis. Both groups were compared for local control (LC) and overall survival (OS). Subgroup analyses were performed for patients who had less radiosensitive tumors (N = 27) and for other patients (N = 157). RESULTS: The LC rate at 1 year was 28% after 30 Gy and 44% after 40 Gy (P = .064). On multivariate analysis, the 40 Gy dose was associated with impro
Název v anglickém jazyce
Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
Popis výsledku anglicky
BACKGROUND: Patients with brain metastases who have a favorable survival prognosis may benefit from intensive treatments, including neurosurgery and radiosurgery. However, many patients cannot receive such treatments, and whole-brain radiotherapy (WBRT)alone is their only option. The most common WBRT schedule is 30 grays (Gy) in 10 fractions. In this retrospective study, the authors investigated whether these patients benefit from a dose escalation beyond 30 Gy. METHODS: Data from 109 patients who received 30 Gy in 10 fractions were compared with 75 patients who received 40 Gy in 20 fractions. All patients had a favorable survival prognosis. Both groups were compared for local control (LC) and overall survival (OS). Subgroup analyses were performed for patients who had less radiosensitive tumors (N = 27) and for other patients (N = 157). RESULTS: The LC rate at 1 year was 28% after 30 Gy and 44% after 40 Gy (P = .064). On multivariate analysis, the 40 Gy dose was associated with impro
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Cancer
ISSN
0008-543X
e-ISSN
—
Svazek periodika
118
Číslo periodika v rámci svazku
15
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
3852-3859
Kód UT WoS článku
000306671300024
EID výsledku v databázi Scopus
—