Micronuclei levels in mothers and their newborns from regions with different types of air pollution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7155" target="_blank" >RIV/00064203:_____/11:7155 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/11:00365843 RIV/00216208:11130/11:7155

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21827774" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21827774</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Micronuclei levels in mothers and their newborns from regions with different types of air pollution

Popis výsledku v původním jazyce

The aim of this study was to analyze genetic damage in human lymphocytes measured using automated image analysis of micronuclei (MN) in a group of 178 mothers and their newborns from two locations in the Czech Republic. The concentrations of benzo[a]pyrene (B[a]B), particulate matter of aerodynamic diameter <2.5 mu m (PM2.5) and benzene were measured by stationary monitoring in the winter season of 2008/2009 in the capital city of Prague and in Ceske Budejovice, a regional city in a rural area. The 3-month mean concentration of B[a]P before delivery was lower in Prague in comparison with Ceske Budejovice: 1.9 +/- 0.5 ng/m(3) vs. 3.2 +/- 0.2 ng/m(3) (p < 0.001). The opposite trend was found for PM2.5 and benzene: 27.0 +/- 2.5 mu g/m(3) and 2.5 +/- 0.5 mu g/m(3) vs. 24.5 +/- 0.7 mu g/m(3) and 2.1 +/- 0.8 mu g/m(3) (p < 0.001) for Prague vs. Ceske Budejovice, respectively. The average age of the mothers was 31 years (range, 18-49 years). The frequencies of MN per 1000 binucleated cells we

Název v anglickém jazyce

Micronuclei levels in mothers and their newborns from regions with different types of air pollution

Popis výsledku anglicky

The aim of this study was to analyze genetic damage in human lymphocytes measured using automated image analysis of micronuclei (MN) in a group of 178 mothers and their newborns from two locations in the Czech Republic. The concentrations of benzo[a]pyrene (B[a]B), particulate matter of aerodynamic diameter <2.5 mu m (PM2.5) and benzene were measured by stationary monitoring in the winter season of 2008/2009 in the capital city of Prague and in Ceske Budejovice, a regional city in a rural area. The 3-month mean concentration of B[a]P before delivery was lower in Prague in comparison with Ceske Budejovice: 1.9 +/- 0.5 ng/m(3) vs. 3.2 +/- 0.2 ng/m(3) (p < 0.001). The opposite trend was found for PM2.5 and benzene: 27.0 +/- 2.5 mu g/m(3) and 2.5 +/- 0.5 mu g/m(3) vs. 24.5 +/- 0.7 mu g/m(3) and 2.1 +/- 0.8 mu g/m(3) (p < 0.001) for Prague vs. Ceske Budejovice, respectively. The average age of the mothers was 31 years (range, 18-49 years). The frequencies of MN per 1000 binucleated cells we

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/2B06088" target="_blank" >2B06088: Využití toxikogenomiky při studiu mechanismů působení cizorodých látek v životním prostředí na lidské zdraví.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis

ISSN

0027-5107

e-ISSN

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Svazek periodika

715

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

72-78

Kód UT WoS článku

000295664200010

EID výsledku v databázi Scopus

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