Effect of stenting on the near-infrared spectroscopy-derived lipid core burden index of carotid artery plaque

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10394882" target="_blank" >RIV/00064203:_____/19:10394882 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/19:10394882

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=6rW9h-gCNB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=6rW9h-gCNB</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4244/EIJ-D-17-01054" target="_blank" >10.4244/EIJ-D-17-01054</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of stenting on the near-infrared spectroscopy-derived lipid core burden index of carotid artery plaque

Popis výsledku v původním jazyce

Aims: Catheter-based intravascular near-infrared spectroscopy (NIRS) detects a lipid signal from atherosclerotic plaque. The aim of this study was to describe the effect of carotid artery stenting (CAS) on the lipid signal in a carotid stenosis. Methods and results: We performed NIRS combined with intravascular ultrasound (IVUS) during 120 CAS procedures. Minimal luminal area (MLA) and plaque burden (PB) at the site of MLA were measured with IVUS and lipid core burden index (LCBI), maximal LCBI in a 4 mm segment of the artery (LCBImax) and LCBI in a 4 mm segment at the site of MLA (LCBImla) with NIRS-derived chemograms. NIRS-IVUS imaging was performed at baseline, after stent implantation and after balloon post-dilatation. The most common lesion type was the fibrocalcific plaque (76%). Lipid-rich plaque (LCBImax &gt;= 400) was present in 33% of carotid stenoses and in 20% at the site of MLA. Median MLA increased significantly from baseline to stent implantation (3.63 mm(2) to 5.56 mm(2), p&lt;0.001) and to post-dilatation (5.56 mm(2) to 12.03 mm(2), p&lt;0.001). Median LCBI, LCBImax and LCBImla significantly decreased from baseline to stent implantation: LCBI (60 to 8, p&lt;0.001), LCBImax (294 to 60, p&lt;0.001) and LCBImla (124 to 0, p&lt;0.001). Post-dilatation of the stent had no further significant effect on median LCBI (8 to 5, p=0.890), LCBImax (60 to 50, p=0.690) and LCBImla (0 to 0, p=0.438). Conclusions: Carotid artery stenting significantly reduced the NIRS-derived lipid core burden index at the stented segment.

Název v anglickém jazyce

Effect of stenting on the near-infrared spectroscopy-derived lipid core burden index of carotid artery plaque

Popis výsledku anglicky

Aims: Catheter-based intravascular near-infrared spectroscopy (NIRS) detects a lipid signal from atherosclerotic plaque. The aim of this study was to describe the effect of carotid artery stenting (CAS) on the lipid signal in a carotid stenosis. Methods and results: We performed NIRS combined with intravascular ultrasound (IVUS) during 120 CAS procedures. Minimal luminal area (MLA) and plaque burden (PB) at the site of MLA were measured with IVUS and lipid core burden index (LCBI), maximal LCBI in a 4 mm segment of the artery (LCBImax) and LCBI in a 4 mm segment at the site of MLA (LCBImla) with NIRS-derived chemograms. NIRS-IVUS imaging was performed at baseline, after stent implantation and after balloon post-dilatation. The most common lesion type was the fibrocalcific plaque (76%). Lipid-rich plaque (LCBImax &gt;= 400) was present in 33% of carotid stenoses and in 20% at the site of MLA. Median MLA increased significantly from baseline to stent implantation (3.63 mm(2) to 5.56 mm(2), p&lt;0.001) and to post-dilatation (5.56 mm(2) to 12.03 mm(2), p&lt;0.001). Median LCBI, LCBImax and LCBImla significantly decreased from baseline to stent implantation: LCBI (60 to 8, p&lt;0.001), LCBImax (294 to 60, p&lt;0.001) and LCBImla (124 to 0, p&lt;0.001). Post-dilatation of the stent had no further significant effect on median LCBI (8 to 5, p=0.890), LCBImax (60 to 50, p=0.690) and LCBImla (0 to 0, p=0.438). Conclusions: Carotid artery stenting significantly reduced the NIRS-derived lipid core burden index at the stented segment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EuroIntervention

ISSN

1774-024X

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

8

Strana od-do

"e289"-"e296"

Kód UT WoS článku

000471064200014

EID výsledku v databázi Scopus

—