Carotid artery plaque composition and distribution: near-infrared spectroscopy and intravascular ultrasound analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412699" target="_blank" >RIV/00216208:11130/20:10412699 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/20:10412699

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S7sEG4e6ZM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S7sEG4e6ZM</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartj/suaa097" target="_blank" >10.1093/eurheartj/suaa097</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Carotid artery plaque composition and distribution: near-infrared spectroscopy and intravascular ultrasound analysis

Popis výsledku v původním jazyce

Most atherosclerotic plaques (APs) form in typical predilection areas of low endothelial shear stress (ESS). On the contrary, previous data hinted that plaques rupture in their proximal parts where accelerated blood flow causes high ESS. It was postulated that high ESS plays an important role in the latter stages of AP formation and in its destabilization. Here, we used near-infrared spectroscopy (NIRS) to analyse the distribution of lipid core based on the presumed exposure to ESS. A total of 117 carotid arteries were evaluated using NIRS and intravascular ultrasound (IVUS) prior to carotid artery stenting. The point of minimal luminal area (MLA) was determined using IVUS. A stepwise analysis of the presence of lipid core was then performed using NIRS. The lipid core presence was quantified as the lipid core burden index (LCBI) within 2 mm wide segments both proximally and distally to the MLA. The analysed vessel was then divided into three 20 mm long thirds (proximal, middle, and distal) for further analysis. The maximal value of LCBI (231.9 +- 245.7) was noted in the segment localized just 2 mm proximally to MLA. The mean LCBI in the middle third was significantly higher than both the proximal (121.4 +- 185.6 vs. 47.0 +- 96.5, P &lt; 0.01) and distal regions (121.4 +- 185.6 vs. 32.4 +- 89.6, P &lt; 0.01). Lipid core was more common in the proximal region when compared with the distal region (mean LCBI 47.0 +- 96.5 vs. 32.4 +- 89.6, P &lt; 0.01).

Název v anglickém jazyce

Carotid artery plaque composition and distribution: near-infrared spectroscopy and intravascular ultrasound analysis

Popis výsledku anglicky

Most atherosclerotic plaques (APs) form in typical predilection areas of low endothelial shear stress (ESS). On the contrary, previous data hinted that plaques rupture in their proximal parts where accelerated blood flow causes high ESS. It was postulated that high ESS plays an important role in the latter stages of AP formation and in its destabilization. Here, we used near-infrared spectroscopy (NIRS) to analyse the distribution of lipid core based on the presumed exposure to ESS. A total of 117 carotid arteries were evaluated using NIRS and intravascular ultrasound (IVUS) prior to carotid artery stenting. The point of minimal luminal area (MLA) was determined using IVUS. A stepwise analysis of the presence of lipid core was then performed using NIRS. The lipid core presence was quantified as the lipid core burden index (LCBI) within 2 mm wide segments both proximally and distally to the MLA. The analysed vessel was then divided into three 20 mm long thirds (proximal, middle, and distal) for further analysis. The maximal value of LCBI (231.9 +- 245.7) was noted in the segment localized just 2 mm proximally to MLA. The mean LCBI in the middle third was significantly higher than both the proximal (121.4 +- 185.6 vs. 47.0 +- 96.5, P &lt; 0.01) and distal regions (121.4 +- 185.6 vs. 32.4 +- 89.6, P &lt; 0.01). Lipid core was more common in the proximal region when compared with the distal region (mean LCBI 47.0 +- 96.5 vs. 32.4 +- 89.6, P &lt; 0.01).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Heart Journal: Supplements

ISSN

1520-765X

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

Suppl F

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

"F38"-"F43"

Kód UT WoS článku

000577169200006

EID výsledku v databázi Scopus

2-s2.0-85101002740