Long-term changes after carotid stenting assessed by intravascular ultrasound and near-infrared spectroscopy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10437428" target="_blank" >RIV/00064203:_____/21:10437428 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/21:10437428

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yJSd1SBTmh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yJSd1SBTmh</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21037/cdt-21-160" target="_blank" >10.21037/cdt-21-160</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term changes after carotid stenting assessed by intravascular ultrasound and near-infrared spectroscopy

Popis výsledku v původním jazyce

BACKGROUND: Long-term effect of carotid stenting (CAS) on the stabilization of the plaque is almost unrecognized. Vascular healing and remodeling might seal the atherosclerotic plaque with neointimal hyperplasia decreasing the vulnerability. We aimed to assess long-term change in the lipid signal, stent and luminal dimensions and restenosis after CAS with the intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) imaging. METHODS: We performed follow-up angiography and NIRS-IVUS imaging of 58 carotid stents in 52 patients. Median time from CAS to the follow-up examination was 31 months (range, 5-56). The lipid signal of the stented segment was calculated from a NIRS-derived chemogram (a spectroscopic map) as the lipid core burden index (LCBI, a dimensionless number from 0 to 1,000). Planimetric and volumetric measurements from IVUS were performed to assess change in minimal stent area (MSA), minimal luminal area (MLA), stent and luminal volume, late stent expansion and percentage in-stent restenosis (ISR) volume. RESULTS: During the follow-up period, the mean (+-SD) LCBI significantly decreased from 32+-56 to 17+-27 (P=0.002). The mean stent volume significantly increased from 717+-302 to 1,019+-429 mm(3) (P&lt;0.001) with mean stent expansion 43%+-24%. The mean luminal volume increased from 717+-302 to 760+-359 mm(3) (P=0.025) due to ISR encroaching 26%+-15% of the stent volume. CONCLUSIONS: Lipid signal decreased during the follow-up period suggesting stabilization of the plaque. Late stent expansion was balanced with neointimal hyperplasia. TRIAL REGISTRATION: The trial is registered under clinicaltrials.gov NCT03141580.

Název v anglickém jazyce

Long-term changes after carotid stenting assessed by intravascular ultrasound and near-infrared spectroscopy

Popis výsledku anglicky

BACKGROUND: Long-term effect of carotid stenting (CAS) on the stabilization of the plaque is almost unrecognized. Vascular healing and remodeling might seal the atherosclerotic plaque with neointimal hyperplasia decreasing the vulnerability. We aimed to assess long-term change in the lipid signal, stent and luminal dimensions and restenosis after CAS with the intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) imaging. METHODS: We performed follow-up angiography and NIRS-IVUS imaging of 58 carotid stents in 52 patients. Median time from CAS to the follow-up examination was 31 months (range, 5-56). The lipid signal of the stented segment was calculated from a NIRS-derived chemogram (a spectroscopic map) as the lipid core burden index (LCBI, a dimensionless number from 0 to 1,000). Planimetric and volumetric measurements from IVUS were performed to assess change in minimal stent area (MSA), minimal luminal area (MLA), stent and luminal volume, late stent expansion and percentage in-stent restenosis (ISR) volume. RESULTS: During the follow-up period, the mean (+-SD) LCBI significantly decreased from 32+-56 to 17+-27 (P=0.002). The mean stent volume significantly increased from 717+-302 to 1,019+-429 mm(3) (P&lt;0.001) with mean stent expansion 43%+-24%. The mean luminal volume increased from 717+-302 to 760+-359 mm(3) (P=0.025) due to ISR encroaching 26%+-15% of the stent volume. CONCLUSIONS: Lipid signal decreased during the follow-up period suggesting stabilization of the plaque. Late stent expansion was balanced with neointimal hyperplasia. TRIAL REGISTRATION: The trial is registered under clinicaltrials.gov NCT03141580.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cardiovascular Diagnosis and Therapy

ISSN

2223-3652

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

10

Strana od-do

1180-1189

Kód UT WoS článku

000744171400001

EID výsledku v databázi Scopus

2-s2.0-85123092502