Lung hyperinflation in patients with obstructive sleep apnoea treated with continuous positive airway pressure – preliminary safety data

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F21%3AN0000232" target="_blank" >RIV/00098892:_____/21:N0000232 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/21:73608310

Výsledek na webu

<a href="http://www.pneumologie.cz/cislo/1892/3-2021/" target="_blank" >http://www.pneumologie.cz/cislo/1892/3-2021/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lung hyperinflation in patients with obstructive sleep apnoea treated with continuous positive airway pressure – preliminary safety data

Popis výsledku v původním jazyce

Objective: Continuous positive airway pressure (CPAP) is currently the gold standard treatment for obstructive sleep apnea (OSA). One of the possible side effects of this therapy may be lung hyperinflation. The aim of this study was to assess the effect of CPAP on lung hyperinflation in patients with OSA. Method: Fifty consecutive OSA patients (43 males) of a mean age of 53.4 years were enrolled into this pilot study. All patients had two body plethysmography measurements taken, one at the time of OSA diagnosis (with AHI > 15), and another after three months of CPAP therapy. Sufficient compliance with therapy was defined as a CPAP use of more than 4 hours per night. Lung hyperinflation was assessed by the residual volume/total lung capacity ratio (RV/TLC). Results: The study found a significant increase in the RV/TLC ratio in CPAP-compliant patients (p = 0.03). The increase did not correlate with the amount of pressure used. The RV/TLC ratio was within physiological ranges both before and after CPAP therapy (mean ratios of 0.38 and 0.40 before and after CPAP therapy, respectively). Conclusion: According to our results, clinically non-significant lung hyperinflation should be considered a possible side effect of CPAP therapy. However, given the small sample size and the minimal difference in the RV/TLC ratio, this conclusion should be verified in a further larger and longer prospective study.

Název v anglickém jazyce

Lung hyperinflation in patients with obstructive sleep apnoea treated with continuous positive airway pressure – preliminary safety data

Popis výsledku anglicky

Objective: Continuous positive airway pressure (CPAP) is currently the gold standard treatment for obstructive sleep apnea (OSA). One of the possible side effects of this therapy may be lung hyperinflation. The aim of this study was to assess the effect of CPAP on lung hyperinflation in patients with OSA. Method: Fifty consecutive OSA patients (43 males) of a mean age of 53.4 years were enrolled into this pilot study. All patients had two body plethysmography measurements taken, one at the time of OSA diagnosis (with AHI > 15), and another after three months of CPAP therapy. Sufficient compliance with therapy was defined as a CPAP use of more than 4 hours per night. Lung hyperinflation was assessed by the residual volume/total lung capacity ratio (RV/TLC). Results: The study found a significant increase in the RV/TLC ratio in CPAP-compliant patients (p = 0.03). The increase did not correlate with the amount of pressure used. The RV/TLC ratio was within physiological ranges both before and after CPAP therapy (mean ratios of 0.38 and 0.40 before and after CPAP therapy, respectively). Conclusion: According to our results, clinically non-significant lung hyperinflation should be considered a possible side effect of CPAP therapy. However, given the small sample size and the minimal difference in the RV/TLC ratio, this conclusion should be verified in a further larger and longer prospective study.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30203 - Respiratory systems

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Studia Pneumologica et Phthiseologica

ISSN

1213-810X

e-ISSN

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Svazek periodika

81

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

121-125

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85170225826