The Relationship Between Leptin and Ventilatory Control in Heart Failure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060563" target="_blank" >RIV/00159816:_____/13:00060563 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1071916413012049" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1071916413012049</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cardfail.2013.10.004" target="_blank" >10.1016/j.cardfail.2013.10.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Relationship Between Leptin and Ventilatory Control in Heart Failure

Popis výsledku v původním jazyce

Background: Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluatedthe relationship of circulating leptin concentration with exercise ventilation in HF patients. Methods and Results: Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptinconcentration of 1.8 +/- 8.9 ng/mL and a highest of 33.3 +/- 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 +/- 6 vs 34 +/- 4; P < .01) as well as in the highest (38 +/- 8 vs 34 +/- 4; P < .05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to

Název v anglickém jazyce

The Relationship Between Leptin and Ventilatory Control in Heart Failure

Popis výsledku anglicky

Background: Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluatedthe relationship of circulating leptin concentration with exercise ventilation in HF patients. Methods and Results: Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptinconcentration of 1.8 +/- 8.9 ng/mL and a highest of 33.3 +/- 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 +/- 6 vs 34 +/- 4; P < .01) as well as in the highest (38 +/- 8 vs 34 +/- 4; P < .05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of cardiac failure

ISSN

1071-9164

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

756-761

Kód UT WoS článku

000328181200006

EID výsledku v databázi Scopus

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