Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061228" target="_blank" >RIV/00159816:_____/14:00061228 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/iep.12094" target="_blank" >http://dx.doi.org/10.1111/iep.12094</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/iep.12094" target="_blank" >10.1111/iep.12094</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model

Popis výsledku v původním jazyce

Oncological research indicated a possible role of statins in the risk reduction of certain malignancies. The purpose of this experiment was to examine the chemopreventive effects of pravastatin alone and in combination with pineal hormone melatonin in the model of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats. Pravastatin was administered dietary (100 mg/kg) and melatonin in a water solution (20 mýg/ml). Chemoprevention began 7 days prior to carcinogen administration and subsequently continued 15 weeks until to autopsy. At autopsy, mammary tumours were removed and prepared for histopathological and immunohistochemical analysis. Parameters of experimental carcinogenesis, mechanism of action (biomarkers of apoptosis, angiogenesis and proliferation) and side effects after long-term treatment in animals were assessed. Pravastatin alone suppressed tumour frequency by 20.5% and average tumour volume by 15% compared with controls. Combined administration of the drugs de

Název v anglickém jazyce

Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model

Popis výsledku anglicky

Oncological research indicated a possible role of statins in the risk reduction of certain malignancies. The purpose of this experiment was to examine the chemopreventive effects of pravastatin alone and in combination with pineal hormone melatonin in the model of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats. Pravastatin was administered dietary (100 mg/kg) and melatonin in a water solution (20 mýg/ml). Chemoprevention began 7 days prior to carcinogen administration and subsequently continued 15 weeks until to autopsy. At autopsy, mammary tumours were removed and prepared for histopathological and immunohistochemical analysis. Parameters of experimental carcinogenesis, mechanism of action (biomarkers of apoptosis, angiogenesis and proliferation) and side effects after long-term treatment in animals were assessed. Pravastatin alone suppressed tumour frequency by 20.5% and average tumour volume by 15% compared with controls. Combined administration of the drugs de

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Experimental Pathology

ISSN

0959-9673

e-ISSN

—

Svazek periodika

96

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

401-410

Kód UT WoS článku

000346972300004

EID výsledku v databázi Scopus

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