Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00063189" target="_blank" >RIV/00159816:_____/14:00063189 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.acthis.2014.09.010" target="_blank" >http://dx.doi.org/10.1016/j.acthis.2014.09.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.acthis.2014.09.010" target="_blank" >10.1016/j.acthis.2014.09.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model

Popis výsledku v původním jazyce

Our previous results indicated significant tumor-suppressive effects of different statins in rat mammary carcinogenesis. The purpose of this experiment was to examine the chemopreventive effects of Pitavastatin alone and in combination with the pineal hormone melatonin in the model of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats. Pitavastatin was administered dietary (10 mg/kg) and melatonin in an aqueous solution (20 mu g/ml). Chemoprevention began 7 days prior tocarcinogen administration and subsequently continued for 15 weeks until autopsy. At autopsy, mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. Compared to controls, Pitavastatin alone reduced average tumorvolume by 58% and lengthened latency by 8 days; on the other hand, the drug increased tumor frequency by 23%. Combined administration of Pitavastatin with melatonin decreased tumor frequency by 23%, tumor volume by 44% and lengthened tumo

Název v anglickém jazyce

Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model

Popis výsledku anglicky

Our previous results indicated significant tumor-suppressive effects of different statins in rat mammary carcinogenesis. The purpose of this experiment was to examine the chemopreventive effects of Pitavastatin alone and in combination with the pineal hormone melatonin in the model of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats. Pitavastatin was administered dietary (10 mg/kg) and melatonin in an aqueous solution (20 mu g/ml). Chemoprevention began 7 days prior tocarcinogen administration and subsequently continued for 15 weeks until autopsy. At autopsy, mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. Compared to controls, Pitavastatin alone reduced average tumorvolume by 58% and lengthened latency by 8 days; on the other hand, the drug increased tumor frequency by 23%. Combined administration of Pitavastatin with melatonin decreased tumor frequency by 23%, tumor volume by 44% and lengthened tumo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Histochemica

ISSN

0065-1281

e-ISSN

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Svazek periodika

116

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

1454-1461

Kód UT WoS článku

000347362000032

EID výsledku v databázi Scopus

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