Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00064322" target="_blank" >RIV/00159816:_____/16:00064322 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00089442 RIV/61989592:15110/16:33162488

Výsledek na webu

<a href="http://dx.doi.org/10.4158/EP15704.OR" target="_blank" >http://dx.doi.org/10.4158/EP15704.OR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4158/EP15704.OR" target="_blank" >10.4158/EP15704.OR</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat?

Popis výsledku v původním jazyce

OBJECTIVE: The aim of this study was to determine reasonable care for NCPHPT patients treated at the Endocrine Clinic. METHODS: The study is based on 218 outpatient cases of primary hyperparathyroidism (PHPT), 187 (86%) of whom were NCPHPT. Subjective complaints, biochemical tests, imaging and treatment outcome for NCPHPT patients were monitored and compared with the same parameters in patients with hypercalcemic hyperparathyroidism (HCPHPT). The number of patients with newly diagnosed NCPHPT who became hypercalcemic and the time period in which it happened were also recorded. RESULTS: Over 6 years of study, in total, 36/187 originally normocalcemic patients became hypercalcemic (19%); 24/36 within 2 years and 2/36 later than after 4 years. MIBI scintigraphy was performed in 103 normocalcemic patients (adenoma was detected in 5 cases) and in 46 hypercalcemic patients with pathologically elevated serum calcium levels of at the time of assesment (adenoma was detected in 32/46 cases). Surgery was performed in 33 patients, 11 of whom were originally normocalcemic (i.e. 6% of all 187 originally normocalcemic patients) and 22 were hypercalcemic from the outset (i.e. 71% of all 31 originally hypercalcemic patients). CONCLUSIONS: Some NCPHPT patients converted to hypercalcemic, mostly within 2 years but some after 4 years or later. Normocalcemic patients should be monitored on long-term basis as it is impossible to anticipate when and which normocalcemic patients will become hypercalcemic. Imaging is much less effective in normocalcemic than in hypercalcemic patients.

Název v anglickém jazyce

Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat?

Popis výsledku anglicky

OBJECTIVE: The aim of this study was to determine reasonable care for NCPHPT patients treated at the Endocrine Clinic. METHODS: The study is based on 218 outpatient cases of primary hyperparathyroidism (PHPT), 187 (86%) of whom were NCPHPT. Subjective complaints, biochemical tests, imaging and treatment outcome for NCPHPT patients were monitored and compared with the same parameters in patients with hypercalcemic hyperparathyroidism (HCPHPT). The number of patients with newly diagnosed NCPHPT who became hypercalcemic and the time period in which it happened were also recorded. RESULTS: Over 6 years of study, in total, 36/187 originally normocalcemic patients became hypercalcemic (19%); 24/36 within 2 years and 2/36 later than after 4 years. MIBI scintigraphy was performed in 103 normocalcemic patients (adenoma was detected in 5 cases) and in 46 hypercalcemic patients with pathologically elevated serum calcium levels of at the time of assesment (adenoma was detected in 32/46 cases). Surgery was performed in 33 patients, 11 of whom were originally normocalcemic (i.e. 6% of all 187 originally normocalcemic patients) and 22 were hypercalcemic from the outset (i.e. 71% of all 31 originally hypercalcemic patients). CONCLUSIONS: Some NCPHPT patients converted to hypercalcemic, mostly within 2 years but some after 4 years or later. Normocalcemic patients should be monitored on long-term basis as it is impossible to anticipate when and which normocalcemic patients will become hypercalcemic. Imaging is much less effective in normocalcemic than in hypercalcemic patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endocrine Practice

ISSN

1530-891X

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

294-301

Kód UT WoS článku

000377968700002

EID výsledku v databázi Scopus

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