Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimers Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067153" target="_blank" >RIV/00159816:_____/17:00067153 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/17:10373766 RIV/00064203:_____/17:10373766

Výsledek na webu

<a href="http://dx.doi.org/10.3389/fneur.2017.00399" target="_blank" >http://dx.doi.org/10.3389/fneur.2017.00399</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fneur.2017.00399" target="_blank" >10.3389/fneur.2017.00399</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimers Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach

Popis výsledku v původním jazyce

Deep gray matter structures are associated with memory and other important functions that are impaired in Alzheimer&apos;s disease (AD) and mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy and deformations in these structures in AD and MCI still need more investigations. In this article, we combined complex volumetry- and vertex-based analysis to investigate the pattern of subregional structural alterations in deep gray matter structures and its association with global clinical scores in AD (n = 30) and MCI patients (n = 30), compared to normal controls (NCs, n = 30). Among all seven pairs of structures, the bilateral hippocampi and nucleus accumbens showed significant atrophy in AD compared with NCs (p &lt; 0.05). But only the subregional atrophy in the dorsal-medial part of the left hippocampus, the ventral part of right hippocampus, and the left nucleus accumbens, the posterior part of the right nucleus accumbens correlated with the worse clinical scores of MMSE and MOCA (p &lt; 0.05). Furthermore, the medial-ventral part of right thalamus significantly shrank and correlated with clinical scores without decreasing in its whole volume (p &gt; 0.05). In conclusion, the atrophy of these four subregions in bilateral hippocampi and nucleus accumbens was associated with cognitive impairment of patients, which might be potential target regions of treatment in AD. The surface analysis could provide additional information to volume comparison in finding the early pathological progress in deep gray matter structures.

Název v anglickém jazyce

Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimers Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach

Popis výsledku anglicky

Deep gray matter structures are associated with memory and other important functions that are impaired in Alzheimer&apos;s disease (AD) and mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy and deformations in these structures in AD and MCI still need more investigations. In this article, we combined complex volumetry- and vertex-based analysis to investigate the pattern of subregional structural alterations in deep gray matter structures and its association with global clinical scores in AD (n = 30) and MCI patients (n = 30), compared to normal controls (NCs, n = 30). Among all seven pairs of structures, the bilateral hippocampi and nucleus accumbens showed significant atrophy in AD compared with NCs (p &lt; 0.05). But only the subregional atrophy in the dorsal-medial part of the left hippocampus, the ventral part of right hippocampus, and the left nucleus accumbens, the posterior part of the right nucleus accumbens correlated with the worse clinical scores of MMSE and MOCA (p &lt; 0.05). Furthermore, the medial-ventral part of right thalamus significantly shrank and correlated with clinical scores without decreasing in its whole volume (p &gt; 0.05). In conclusion, the atrophy of these four subregions in bilateral hippocampi and nucleus accumbens was associated with cognitive impairment of patients, which might be potential target regions of treatment in AD. The surface analysis could provide additional information to volume comparison in finding the early pathological progress in deep gray matter structures.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Neurology

ISSN

1664-2295

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

AUG

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

399

Kód UT WoS článku

000407592700001

EID výsledku v databázi Scopus

—