Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068889" target="_blank" >RIV/00159816:_____/18:00068889 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00104102

Výsledek na webu

<a href="http://dx.doi.org/10.1055/s-0037-1607396" target="_blank" >http://dx.doi.org/10.1055/s-0037-1607396</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0037-1607396" target="_blank" >10.1055/s-0037-1607396</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation

Popis výsledku v původním jazyce

Introduction We analyzed the results of vagus nerve stimulation (VNS) on older patients and patients with long-lasting epilepsy and included severely intellectually disabled patients. Patients and Methods A total of 103 adults with VNS implanted from 2005 to 2014 were studied. The responder rates, that is, the percentage of VNS patients who responded to VNS, classified as seizure reduction50% (50R) and seizure reduction90% (90R), were compared in defined age groups (&lt; 40 and40 years, and&lt;50 and50 years) and epilepsy duration groups (&lt; 20 and20 years,&lt;30 and30 years, and&lt;40 and40 years) at the 1-year follow-up visit and the last follow-up visit (at least 2 years after surgery). The age distributions and responder rates were also studied in patients with an intellectual disability. Results The analysis did not confirm a significantly lower 50R or 90R rate in patients40,50, or60 years when compared with their younger counterparts, but the 50R rate increase during follow-up care was the lowest in patients50 and60 years. The highest percentage of patients with an intellectual disability in the group&lt;40 years of age did not adversely affect the 50R rate. Longer epilepsy duration was not confirmed as a negative predictor of VNS outcome. There was a significantly higher 50R rate in patients with epilepsy duration20 years (at the last follow-up visit) and a higher 90R rate in patients with epilepsy duration30 years (at the 1-year follow-up visit). The increase in the 50R rate during follow-up care was lower in patients with epilepsy durations30 and40 years. Conclusions The study did not find worse VNS outcomes, as defined by the 50R or 90R rate, in older adult patients or in patients with a longer epilepsy duration. The increasing stimulation effect over time is less marked in older patients and in patients with longer epilepsy duration.

Název v anglickém jazyce

Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation

Popis výsledku anglicky

Introduction We analyzed the results of vagus nerve stimulation (VNS) on older patients and patients with long-lasting epilepsy and included severely intellectually disabled patients. Patients and Methods A total of 103 adults with VNS implanted from 2005 to 2014 were studied. The responder rates, that is, the percentage of VNS patients who responded to VNS, classified as seizure reduction50% (50R) and seizure reduction90% (90R), were compared in defined age groups (&lt; 40 and40 years, and&lt;50 and50 years) and epilepsy duration groups (&lt; 20 and20 years,&lt;30 and30 years, and&lt;40 and40 years) at the 1-year follow-up visit and the last follow-up visit (at least 2 years after surgery). The age distributions and responder rates were also studied in patients with an intellectual disability. Results The analysis did not confirm a significantly lower 50R or 90R rate in patients40,50, or60 years when compared with their younger counterparts, but the 50R rate increase during follow-up care was the lowest in patients50 and60 years. The highest percentage of patients with an intellectual disability in the group&lt;40 years of age did not adversely affect the 50R rate. Longer epilepsy duration was not confirmed as a negative predictor of VNS outcome. There was a significantly higher 50R rate in patients with epilepsy duration20 years (at the last follow-up visit) and a higher 90R rate in patients with epilepsy duration30 years (at the 1-year follow-up visit). The increase in the 50R rate during follow-up care was lower in patients with epilepsy durations30 and40 years. Conclusions The study did not find worse VNS outcomes, as defined by the 50R or 90R rate, in older adult patients or in patients with a longer epilepsy duration. The increasing stimulation effect over time is less marked in older patients and in patients with longer epilepsy duration.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurological Surgery Part A-Central European Neurosurgery

ISSN

2193-6315

e-ISSN

—

Svazek periodika

79

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

152-158

Kód UT WoS článku

000426299500008

EID výsledku v databázi Scopus

2-s2.0-85035358015