Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078044" target="_blank" >RIV/00159816:_____/23:00078044 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/23:00078044 RIV/00216224:14110/23:00134637

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00381-023-05992-3" target="_blank" >https://link.springer.com/article/10.1007/s00381-023-05992-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00381-023-05992-3" target="_blank" >10.1007/s00381-023-05992-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study

Popis výsledku v původním jazyce

PurposeA retrospective study, based on a prospectively built database, presents the results of long-term follow-up care of pediatric vagus nerve stimulation (VNS) patients in terms of seizure outcome, surgical aspects, the potential impact of maturation, and medication changes.MethodsFrom a prospectively built database, 16 VNS patients (median age 12.0 years, range 6.0 to 16.0 years; median seizure duration 6.5 years, range 2.0 to 15.5 years) followed for at least 10 years were graded as non-responder - NR (seizure frequency reduction &lt; 50%), responder - R (reduction &gt;= 50% and &lt; 80%), and 80% responder - 80R (reduction &gt;= 80%). Data about surgical aspects (battery replacement, system complications), seizure dynamics, and medication changes were taken from the database.ResultsThe early percentages of good results (80R + R) were 43.8% (year 1), 50.0% (year 2), and 43.8% (year 3). These percentages remained stable between years 10 and 12 (50% year 10; 46.7% year 11; 50% year 12) and increased in years 16 (60%) and 17 (75%). Depleted batteries were replaced in ten patients, six of whom were either R or 80R. In the four NR, the indication for replacement was improved quality of life. Three patients had VNS explanted or switched off-one had repeated asystolia and two were NR. The effect of hormonal changes in menarche on seizure was not proven. During the study, antiseizure medication was changed in all patients.ConclusionsThe study proved the efficacy and safety of VNS in pediatric patients over an exceptionally long follow-up period. The demand for battery replacements indicates a positive treatment effect.

Název v anglickém jazyce

Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study

Popis výsledku anglicky

PurposeA retrospective study, based on a prospectively built database, presents the results of long-term follow-up care of pediatric vagus nerve stimulation (VNS) patients in terms of seizure outcome, surgical aspects, the potential impact of maturation, and medication changes.MethodsFrom a prospectively built database, 16 VNS patients (median age 12.0 years, range 6.0 to 16.0 years; median seizure duration 6.5 years, range 2.0 to 15.5 years) followed for at least 10 years were graded as non-responder - NR (seizure frequency reduction &lt; 50%), responder - R (reduction &gt;= 50% and &lt; 80%), and 80% responder - 80R (reduction &gt;= 80%). Data about surgical aspects (battery replacement, system complications), seizure dynamics, and medication changes were taken from the database.ResultsThe early percentages of good results (80R + R) were 43.8% (year 1), 50.0% (year 2), and 43.8% (year 3). These percentages remained stable between years 10 and 12 (50% year 10; 46.7% year 11; 50% year 12) and increased in years 16 (60%) and 17 (75%). Depleted batteries were replaced in ten patients, six of whom were either R or 80R. In the four NR, the indication for replacement was improved quality of life. Three patients had VNS explanted or switched off-one had repeated asystolia and two were NR. The effect of hormonal changes in menarche on seizure was not proven. During the study, antiseizure medication was changed in all patients.ConclusionsThe study proved the efficacy and safety of VNS in pediatric patients over an exceptionally long follow-up period. The demand for battery replacements indicates a positive treatment effect.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

<a href="/cs/project/NV19-04-00343" target="_blank" >NV19-04-00343: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Childs Nervous System

ISSN

0256-7040

e-ISSN

1433-0350

Svazek periodika

39

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

3215-3224

Kód UT WoS článku

000992036000001

EID výsledku v databázi Scopus

2-s2.0-85160276810