Single-center long-term results of vagus nerve stimulation for epilepsy: A 10-17 year follow-up study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068885" target="_blank" >RIV/00159816:_____/18:00068885 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00104673

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.seizure.2018.04.022" target="_blank" >http://dx.doi.org/10.1016/j.seizure.2018.04.022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.seizure.2018.04.022" target="_blank" >10.1016/j.seizure.2018.04.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Single-center long-term results of vagus nerve stimulation for epilepsy: A 10-17 year follow-up study

Popis výsledku v původním jazyce

Purpose: The paper presents a long-term follow-up study of VNS patients, analyzing seizure outcome, medication changes, and surgical problems. Method: 74 adults with VMS for 10 to 17 years were evaluated yearly as: non-responder - NR (seizure frequency reduction &lt;50%), responder - R (reduction &gt;= 50% and &lt;90%), and 90% responder - 90R (reduction &gt;= 90%). Delayed R or 90R (&gt;= 4 years after surgery), patients with antiepileptic medication changes and battery or complete system replacement were identified. Statistical analysis of potential outcome predictors (age, seizure duration, MRI, seizure type) was performed. Results: The rates of R and 90R related to the patients with outcome data available for the study years 1, 2, 10, and 17 were for R 38.4%, 51.4%, 63.6%, and 77.8%, and for 90R 1.4%, 5.6%, 15.1%, and 11.1%. The absolute numbers of R and 90R increased until years 2 and 6. Antiepileptic therapy was changed in 62 patients (87.9%). There were 11 delayed R and four delayed 90R, with medication changes in the majority. At least one battery replacement was performed in 51 patients (68.9%), 49 of whom R or 90R. VNS system was completely replaced in 7 patients (9.5%) and explanted in 7 NR (9.5%). No significant predictor of VNS outcome was found. Conclusions: After an initial increase, the rate of R and 90R remains stable in long-term follow-up. The changes of antiepileptic treatment in most patients potentially influence the outcome. Battery replacements or malfunctioning system exchange reflect the patient&apos;s satisfaction and correlate with good outcomes. (C) 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Název v anglickém jazyce

Single-center long-term results of vagus nerve stimulation for epilepsy: A 10-17 year follow-up study

Popis výsledku anglicky

Purpose: The paper presents a long-term follow-up study of VNS patients, analyzing seizure outcome, medication changes, and surgical problems. Method: 74 adults with VMS for 10 to 17 years were evaluated yearly as: non-responder - NR (seizure frequency reduction &lt;50%), responder - R (reduction &gt;= 50% and &lt;90%), and 90% responder - 90R (reduction &gt;= 90%). Delayed R or 90R (&gt;= 4 years after surgery), patients with antiepileptic medication changes and battery or complete system replacement were identified. Statistical analysis of potential outcome predictors (age, seizure duration, MRI, seizure type) was performed. Results: The rates of R and 90R related to the patients with outcome data available for the study years 1, 2, 10, and 17 were for R 38.4%, 51.4%, 63.6%, and 77.8%, and for 90R 1.4%, 5.6%, 15.1%, and 11.1%. The absolute numbers of R and 90R increased until years 2 and 6. Antiepileptic therapy was changed in 62 patients (87.9%). There were 11 delayed R and four delayed 90R, with medication changes in the majority. At least one battery replacement was performed in 51 patients (68.9%), 49 of whom R or 90R. VNS system was completely replaced in 7 patients (9.5%) and explanted in 7 NR (9.5%). No significant predictor of VNS outcome was found. Conclusions: After an initial increase, the rate of R and 90R remains stable in long-term follow-up. The changes of antiepileptic treatment in most patients potentially influence the outcome. Battery replacements or malfunctioning system exchange reflect the patient&apos;s satisfaction and correlate with good outcomes. (C) 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Seizure-European Journal of Epilepsy

ISSN

1059-1311

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

JUL 2018

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

41-47

Kód UT WoS článku

000437818500009

EID výsledku v databázi Scopus

2-s2.0-85046743653