Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00080530" target="_blank" >RIV/00159816:_____/24:00080530 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00135902

Výsledek na webu

<a href="https://www.nature.com/articles/s41531-024-00656-8" target="_blank" >https://www.nature.com/articles/s41531-024-00656-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41531-024-00656-8" target="_blank" >10.1038/s41531-024-00656-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS

Popis výsledku v původním jazyce

Beta hypersynchrony was recently introduced into clinical practice in Parkinson&apos;s disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication &quot;off&quot; state. Coupling between beta power and HFOs is known to be a correlate of the PD &quot;off&quot; state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.

Název v anglickém jazyce

Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS

Popis výsledku anglicky

Beta hypersynchrony was recently introduced into clinical practice in Parkinson&apos;s disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication &quot;off&quot; state. Coupling between beta power and HFOs is known to be a correlate of the PD &quot;off&quot; state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA21-25953S" target="_blank" >GA21-25953S: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

npj Parkinsons Disease

ISSN

2373-8057

e-ISSN

2373-8057

Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

40

Kód UT WoS článku

001169223800001

EID výsledku v databázi Scopus

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