Post-Operative Atrial Fibrillation: Novel Predictive Value of CT-Derived Adipose Tissue Density in Minimally Invasive Mitral Surgery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082577" target="_blank" >RIV/00159816:_____/25:00082577 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00143237 RIV/61988987:17110/25:A2603DNO RIV/00216208:11120/25:43929521

Výsledek na webu

<a href="https://www.biomed.cas.cz/physiolres/pdf/2025/74_S117.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2025/74_S117.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.935754" target="_blank" >10.33549/physiolres.935754</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Post-Operative Atrial Fibrillation: Novel Predictive Value of CT-Derived Adipose Tissue Density in Minimally Invasive Mitral Surgery

Popis výsledku v původním jazyce

Postoperative atrial fibrillation (POAF) remains a significant complication following minimally invasive thoracoscopic mitral valve surgery (MITMVS), yet current risk prediction models inadequately capture the underlying metabolic determinants of arrhythmogenesis. We investigated whether computed tomography (CT)-derived body composition parameters, as markers of metabolic status, could predict POAF risk in patients undergoing mitral valve repair. We retrospectively studied 104 consecutive MITMVS patients (2014-2023). Preoperative CT scans quantified skeletal muscle index, muscle density, and visceral/subcutaneous adipose tissue. Patients were grouped by preexisting atrial fibrillation (AF) with concurrent Maze (n=48) vs. no AF history (n=56). The primary outcome was POAF development. Higher visceral (VAT) and subcutaneous (SAT) adipose tissue density showed associations with increased POAF odds in multivariable analysis (VAT: OR 1.075, 95 % CI: 1.010;1.149, p=0.026; SAT: OR 1.073, 95 % CI: 1.011;1.146, p=0.025). Quartile analysis revealed a striking 5.5-fold increased POAF risk in the highest VAT density quartile compared to the lowest (42.3 % vs. 7.7 %). Notably, the relationship between intramuscular adipose tissue (IMAT) density and POAF differed between groups (interaction p=0.029), with a positive association in patients without prior AF (OR 1.167, 95 % CI: 1.011;1.377, p=0.047), but no significant relationship in those with preexisting AF (p=0.175). CT-derived tissue quality parameters, particularly VAT density, demonstrate robust associations with POAF risk following MITMVS. These findings establish preoperative CT-based metabolic assessment as a promising tool for perioperative risk stratification without additional testing burden.

Název v anglickém jazyce

Post-Operative Atrial Fibrillation: Novel Predictive Value of CT-Derived Adipose Tissue Density in Minimally Invasive Mitral Surgery

Popis výsledku anglicky

Postoperative atrial fibrillation (POAF) remains a significant complication following minimally invasive thoracoscopic mitral valve surgery (MITMVS), yet current risk prediction models inadequately capture the underlying metabolic determinants of arrhythmogenesis. We investigated whether computed tomography (CT)-derived body composition parameters, as markers of metabolic status, could predict POAF risk in patients undergoing mitral valve repair. We retrospectively studied 104 consecutive MITMVS patients (2014-2023). Preoperative CT scans quantified skeletal muscle index, muscle density, and visceral/subcutaneous adipose tissue. Patients were grouped by preexisting atrial fibrillation (AF) with concurrent Maze (n=48) vs. no AF history (n=56). The primary outcome was POAF development. Higher visceral (VAT) and subcutaneous (SAT) adipose tissue density showed associations with increased POAF odds in multivariable analysis (VAT: OR 1.075, 95 % CI: 1.010;1.149, p=0.026; SAT: OR 1.073, 95 % CI: 1.011;1.146, p=0.025). Quartile analysis revealed a striking 5.5-fold increased POAF risk in the highest VAT density quartile compared to the lowest (42.3 % vs. 7.7 %). Notably, the relationship between intramuscular adipose tissue (IMAT) density and POAF differed between groups (interaction p=0.029), with a positive association in patients without prior AF (OR 1.167, 95 % CI: 1.011;1.377, p=0.047), but no significant relationship in those with preexisting AF (p=0.175). CT-derived tissue quality parameters, particularly VAT density, demonstrate robust associations with POAF risk following MITMVS. These findings establish preoperative CT-based metabolic assessment as a promising tool for perioperative risk stratification without additional testing burden.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

1802-9973

Svazek periodika

74

Číslo periodika v rámci svazku

S1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

12

Strana od-do

"S117"-"S128"

Kód UT WoS článku

001690902000009

EID výsledku v databázi Scopus

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