Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125073" target="_blank" >RIV/00179906:_____/12:10125073 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/12:00060118 RIV/00209805:_____/12:#0000342 RIV/00216208:11150/12:10125073

Výsledek na webu

<a href="http://www.translational-medicine.com/content/10/1/55" target="_blank" >http://www.translational-medicine.com/content/10/1/55</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1479-5876-10-55" target="_blank" >10.1186/1479-5876-10-55</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

Popis výsledku v původním jazyce

Background: There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers. Our aim was to identify miRNA signature that can distinguish the blood serum of RCC patients and matched healthy controls and validate identified miRNAs as potential biomarkers for RCC. Methods: Inthe screening phase of the study, blood serum of 15 RCC patients and 12 matched healthy controls were analyzed by use of the TaqMan Low-Density Arrays enabling parallel identification of expression levels of 667 miRNAs through qRT-PCR-based approach. Inthe validation phase, identified miRNAs were further evaluated on the independent group of 90 RCC patients and 35 matched healthy controls by use of individual qRT-PCR assays and statistically evaluated. Results: We identified 30 miRNAs d

Název v anglickém jazyce

Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

Popis výsledku anglicky

Background: There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers. Our aim was to identify miRNA signature that can distinguish the blood serum of RCC patients and matched healthy controls and validate identified miRNAs as potential biomarkers for RCC. Methods: Inthe screening phase of the study, blood serum of 15 RCC patients and 12 matched healthy controls were analyzed by use of the TaqMan Low-Density Arrays enabling parallel identification of expression levels of 667 miRNAs through qRT-PCR-based approach. Inthe validation phase, identified miRNAs were further evaluated on the independent group of 90 RCC patients and 35 matched healthy controls by use of individual qRT-PCR assays and statistically evaluated. Results: We identified 30 miRNAs d

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Translational Medicine

ISSN

1479-5876

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

22.3. 2012 (1)

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000303352600001

EID výsledku v databázi Scopus

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