Increase of serum interleukin 6 and interferon γ is associated with the number of impulses in patients with supraventricular arrhythmias treated with radiofrequency catheter ablation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10317094" target="_blank" >RIV/00179906:_____/16:10317094 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/16:10317094

Výsledek na webu

<a href="http://dx.doi.org/10.5507/bp.2015.038" target="_blank" >http://dx.doi.org/10.5507/bp.2015.038</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2015.038" target="_blank" >10.5507/bp.2015.038</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increase of serum interleukin 6 and interferon γ is associated with the number of impulses in patients with supraventricular arrhythmias treated with radiofrequency catheter ablation

Popis výsledku v původním jazyce

BACKGROUND:Activation of the immune system plays a pathogenic role in the process of myocardial remodeling in patients with supraventricular arrhythmias. The intensity of this process is associated with the effectiveness of electrical cardioversion and radiofrequency catheter ablation (RFA). The aim of this study was to test the ability of the biochip microarray to detect immune parameters in patients with supraventricular arrhythmias undergoing RFA treatment. METHODS: We used a biochip-based microarray system to determine multiple immune parameters in a group of 35 patients who had undergone RFA for atrioventricular nodal reentry tachycardia (AVNRT), atrial flutter (AFL) and atrial fibrillation (AF). RESULTS: Before the procedure, serum IL-6 and VEGF levels were significantly increased in patients with atrial fibrillation compared to patients with AVNRT (IL-6: 6.4+-6.3 ng/L vs. 1.5+-0.7 ng/L, P < 0.01; VEGF: 132.4+-74 ng/L vs. 88.5+-56.4 ng/L, P < 0.01). After the procedure, serum IL-6, VEGF, IFN-γ and MCP-1 levels significantly increased compared to baseline (IL-6: 5.2+-4.8 ng/L vs. 2.9+-2.1 ng/L, P < 0.01; VEGF: 195.8+-160 ng/L vs. 119.8+- 110 ng/L, P < 0.05; IFN-γ: 3.1+-1.2 ng/L vs. 2.3+-0.6 ng/L, P < 0.05; MCP-1: 104.1+-84.5 ng/L vs. 54.5+-50 ng/L, P < 0.05). Serum IL-6 and IFN-γ were associated with the number of RFA applications (IL-6: r = 0.56, n 33; IFN-γ: r = 0.47, n 33). CONCLUSIONS: This study showed that biochip-based microarray can be useful in the detection of immune activation in patients with arrhythmias and can detect myocardial injury after RF procedures.

Název v anglickém jazyce

Increase of serum interleukin 6 and interferon γ is associated with the number of impulses in patients with supraventricular arrhythmias treated with radiofrequency catheter ablation

Popis výsledku anglicky

BACKGROUND:Activation of the immune system plays a pathogenic role in the process of myocardial remodeling in patients with supraventricular arrhythmias. The intensity of this process is associated with the effectiveness of electrical cardioversion and radiofrequency catheter ablation (RFA). The aim of this study was to test the ability of the biochip microarray to detect immune parameters in patients with supraventricular arrhythmias undergoing RFA treatment. METHODS: We used a biochip-based microarray system to determine multiple immune parameters in a group of 35 patients who had undergone RFA for atrioventricular nodal reentry tachycardia (AVNRT), atrial flutter (AFL) and atrial fibrillation (AF). RESULTS: Before the procedure, serum IL-6 and VEGF levels were significantly increased in patients with atrial fibrillation compared to patients with AVNRT (IL-6: 6.4+-6.3 ng/L vs. 1.5+-0.7 ng/L, P < 0.01; VEGF: 132.4+-74 ng/L vs. 88.5+-56.4 ng/L, P < 0.01). After the procedure, serum IL-6, VEGF, IFN-γ and MCP-1 levels significantly increased compared to baseline (IL-6: 5.2+-4.8 ng/L vs. 2.9+-2.1 ng/L, P < 0.01; VEGF: 195.8+-160 ng/L vs. 119.8+- 110 ng/L, P < 0.05; IFN-γ: 3.1+-1.2 ng/L vs. 2.3+-0.6 ng/L, P < 0.05; MCP-1: 104.1+-84.5 ng/L vs. 54.5+-50 ng/L, P < 0.05). Serum IL-6 and IFN-γ were associated with the number of RFA applications (IL-6: r = 0.56, n 33; IFN-γ: r = 0.47, n 33). CONCLUSIONS: This study showed that biochip-based microarray can be useful in the detection of immune activation in patients with arrhythmias and can detect myocardial injury after RF procedures.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

160

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

106-110

Kód UT WoS článku

000373390800013

EID výsledku v databázi Scopus

2-s2.0-84962339953