The role of AGR2 and AGR3 in cancer: similar but not identical

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000605" target="_blank" >RIV/00209805:_____/15:#0000605 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ejcb.2015.01.002" target="_blank" >http://dx.doi.org/10.1016/j.ejcb.2015.01.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejcb.2015.01.002" target="_blank" >10.1016/j.ejcb.2015.01.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of AGR2 and AGR3 in cancer: similar but not identical

Popis výsledku v původním jazyce

In the past decades, highly related members of the protein disulphide isomerase family, anterior gradient protein AGR2 and AGR3, attracted researchers? attention due to their putative involvement in developmental processes and carcinogenesis. While AGR2has been widely demonstrated as a metastasis-related protein whose elevated expression predicts worse patient outcome, little is known about AGR3?s role in tumour biology. Thus, we aim to confront the issue of AGR3 function in physiology and pathology inthe following review by comparing this protein with the better-described homologue AGR2. Relying on available data and in silico analyses, we show that AGR proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. Further, we discuss plausible roles of both proteins in tumour-associated processes such as differentiation, proliferation, migration, invasion and metastasis. This work brings new hints and stimulates further thoughts on hi

Název v anglickém jazyce

The role of AGR2 and AGR3 in cancer: similar but not identical

Popis výsledku anglicky

In the past decades, highly related members of the protein disulphide isomerase family, anterior gradient protein AGR2 and AGR3, attracted researchers? attention due to their putative involvement in developmental processes and carcinogenesis. While AGR2has been widely demonstrated as a metastasis-related protein whose elevated expression predicts worse patient outcome, little is known about AGR3?s role in tumour biology. Thus, we aim to confront the issue of AGR3 function in physiology and pathology inthe following review by comparing this protein with the better-described homologue AGR2. Relying on available data and in silico analyses, we show that AGR proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. Further, we discuss plausible roles of both proteins in tumour-associated processes such as differentiation, proliferation, migration, invasion and metastasis. This work brings new hints and stimulates further thoughts on hi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European journal of cell biology

ISSN

0171-9335

e-ISSN

—

Svazek periodika

94

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

139-147

Kód UT WoS článku

000353527600002

EID výsledku v databázi Scopus

2-s2.0-84925248991