Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078056" target="_blank" >RIV/00209805:_____/18:00078056 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/18:00105814 RIV/65269705:_____/18:00069233

Výsledek na webu

<a href="https://www.degruyter.com/doi/10.1515/cclm-2017-0958" target="_blank" >https://www.degruyter.com/doi/10.1515/cclm-2017-0958</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cclm-2017-0958" target="_blank" >10.1515/cclm-2017-0958</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

Popis výsledku v původním jazyce

Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells release. For these reasons, CSF is a potential source of diagnostic biomarkers of many CNS diseases, including brain tumors. Recent studies have revealed that CSF also contains circulating microRNAs (miRNAs), short non-coding RNAs that have been described as biomarkers in many cancers. However, CSF miRNAs are difficult to detect, which is why researchers face major challenges, including technological difficulties in its detection and its lack of standardization. Therefore, this review aims (i) to highlight the potential of CSF miRNAs as diagnostic, prognostic and predictive biomarkers in brain tumors, and (ii) to summarize technological approaches for detection of CSF miRNAs.

Název v anglickém jazyce

Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

Popis výsledku anglicky

Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells release. For these reasons, CSF is a potential source of diagnostic biomarkers of many CNS diseases, including brain tumors. Recent studies have revealed that CSF also contains circulating microRNAs (miRNAs), short non-coding RNAs that have been described as biomarkers in many cancers. However, CSF miRNAs are difficult to detect, which is why researchers face major challenges, including technological difficulties in its detection and its lack of standardization. Therefore, this review aims (i) to highlight the potential of CSF miRNAs as diagnostic, prognostic and predictive biomarkers in brain tumors, and (ii) to summarize technological approaches for detection of CSF miRNAs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical chemistry and laboratory medicine

ISSN

1434-6621

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

869-879

Kód UT WoS článku

000431126000012

EID výsledku v databázi Scopus

2-s2.0-85042362378