Benefits of 18F-FET PET in preoperative assessment of glioma heterogeneity demonstrated in two case reports

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F21%3A00078861" target="_blank" >RIV/00209805:_____/21:00078861 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2021-4-9/benefits-of-18f-fet-pet-in-preoperative-assessment-of-glioma-heterogeneity-demonstrated-in-two-case-reports-128182" target="_blank" >https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2021-4-9/benefits-of-18f-fet-pet-in-preoperative-assessment-of-glioma-heterogeneity-demonstrated-in-two-case-reports-128182</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2021405" target="_blank" >10.48095/cccsnn2021405</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Benefits of 18F-FET PET in preoperative assessment of glioma heterogeneity demonstrated in two case reports

Popis výsledku v původním jazyce

Magnetic resonance imaging is still considered the gold standard of dia gnostic algorithms in gliomas. However, especially in gliomas with atypical enhancement patterns, PET could improve evaluation by monitoring processes such as cell proliferation, membrane bio synthesis, and glucose consumption [1]. Radiolabeled amino acids are frequently used PET tracers due to their high signal-to-noise ratio. In contrast to glucose derivatives, the uptake of amino acids in infl ammatory cells is lower, which makes them more specific for tumor detection [2]. Moreover, amino acids are accumulated in malignant cells owing to increased expression of type L amino acid transporters in tumor vasculature [3]. Additionally, the counter-transport system A is overexpressed in neoplastic cells and seems to correlate positively with tumor cell growth rate [4]. Elevated transport of amino acids is a result of increased protein synthesis and also refl ects the increased demand by tumor cell metabolism [5]. Currently, [18F]-fl uoro-ethyl-L-tyrosine (18F-FET) is a promising amino acid radiotracer in dia gnosing low-grade glioma and its possible hot spots. Besides diff usion through the impaired blood-brain barrier (BBB), 18F-FET can additionally cross the BBB via endothelial L-transporters [6]. It also retains a relatively long half-life of 109 min. 18F-FET can be produced in large amounts for clinical purposes and is applicable in a satellite concept. In contrast, 3&apos;-deoxy-3&apos;-18F-fl uorothymidine (18F-FLT) is a radiolabeled analog of the DNA nucleoside that enters cells by active transport through nucleoside transporters and by passive diff usion [7]. As it does not cross the intact BBB [8] and refl ects tissue proliferation rate [9], the dia gnostic yield of 18F-FLT in low-grade gliomas (LGG) is questionable because of their more indolent bio logical course.

Název v anglickém jazyce

Benefits of 18F-FET PET in preoperative assessment of glioma heterogeneity demonstrated in two case reports

Popis výsledku anglicky

Magnetic resonance imaging is still considered the gold standard of dia gnostic algorithms in gliomas. However, especially in gliomas with atypical enhancement patterns, PET could improve evaluation by monitoring processes such as cell proliferation, membrane bio synthesis, and glucose consumption [1]. Radiolabeled amino acids are frequently used PET tracers due to their high signal-to-noise ratio. In contrast to glucose derivatives, the uptake of amino acids in infl ammatory cells is lower, which makes them more specific for tumor detection [2]. Moreover, amino acids are accumulated in malignant cells owing to increased expression of type L amino acid transporters in tumor vasculature [3]. Additionally, the counter-transport system A is overexpressed in neoplastic cells and seems to correlate positively with tumor cell growth rate [4]. Elevated transport of amino acids is a result of increased protein synthesis and also refl ects the increased demand by tumor cell metabolism [5]. Currently, [18F]-fl uoro-ethyl-L-tyrosine (18F-FET) is a promising amino acid radiotracer in dia gnosing low-grade glioma and its possible hot spots. Besides diff usion through the impaired blood-brain barrier (BBB), 18F-FET can additionally cross the BBB via endothelial L-transporters [6]. It also retains a relatively long half-life of 109 min. 18F-FET can be produced in large amounts for clinical purposes and is applicable in a satellite concept. In contrast, 3&apos;-deoxy-3&apos;-18F-fl uorothymidine (18F-FLT) is a radiolabeled analog of the DNA nucleoside that enters cells by active transport through nucleoside transporters and by passive diff usion [7]. As it does not cross the intact BBB [8] and refl ects tissue proliferation rate [9], the dia gnostic yield of 18F-FLT in low-grade gliomas (LGG) is questionable because of their more indolent bio logical course.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Československá neurologie a neurochirurgie

ISSN

0301-0597

e-ISSN

—

Svazek periodika

84

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

405-409

Kód UT WoS článku

000738908000015

EID výsledku v databázi Scopus

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