c-erbB-2 oncoprotein and other tissue prognostic factors in benign and malignant breast

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F99%3A00000018" target="_blank" >RIV/00209805:_____/99:00000018 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

c-erbB-2 oncoprotein and other tissue prognostic factors in benign and malignant breast

Popis výsledku v původním jazyce

To the possible risk factors of relapse in breast cancer belong selected oncogenes and products of their expression. In retrospective study using breast tissue material we attempted 1) to analyze c-erbB-2 oncoprotein in breast cyst fluids of benign fibrocystic disease, in extracts of dysplastic tissues, fibroadenomas, phylloid tumors, and breast cancers, 2) to compare the results of the c-erbB-2 ELISA estimation with immunohistochemical localization, 3) to correlate these results with medical history data, with available biochemical examinations, and with preliminary results of telomerase activity determinations as a measure of immortal character of tumor tissue. The expression of c-erbB-2 oncoprotein differs significantly in benign and malignant breast tumors, the highest concentrations were found in the breast cancer group (37 % of malignant specimens were higher than cut-off value 100 kU/g protein).

Název v anglickém jazyce

c-erbB-2 oncoprotein and other tissue prognostic factors in benign and malignant breast

Popis výsledku anglicky

To the possible risk factors of relapse in breast cancer belong selected oncogenes and products of their expression. In retrospective study using breast tissue material we attempted 1) to analyze c-erbB-2 oncoprotein in breast cyst fluids of benign fibrocystic disease, in extracts of dysplastic tissues, fibroadenomas, phylloid tumors, and breast cancers, 2) to compare the results of the c-erbB-2 ELISA estimation with immunohistochemical localization, 3) to correlate these results with medical history data, with available biochemical examinations, and with preliminary results of telomerase activity determinations as a measure of immortal character of tumor tissue. The expression of c-erbB-2 oncoprotein differs significantly in benign and malignant breast tumors, the highest concentrations were found in the breast cancer group (37 % of malignant specimens were higher than cut-off value 100 kU/g protein).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

1999

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Tumor Marker Oncology

ISSN

0886-3849

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

neuv.

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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