Prognostic significance of c-erbB-2 (HER-2/neu) oncoprotein and other parameters in benign and malignant breast tumor tissue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F99%3A00000024" target="_blank" >RIV/00209805:_____/99:00000024 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic significance of c-erbB-2 (HER-2/neu) oncoprotein and other parameters in benign and malignant breast tumor tissue

Popis výsledku v původním jazyce

The overexpression of c-erbB-2 (HER2/neu) oncoprotein was analyzed quantitatively by ELISA in tissue extracts of benign and malignant breast tumors (N= 38 and 145, resp.). The level of this oncoprotein was above the cut-off value (100 kU/g protein) in 5%of dysplastic tissues and in 37 % of breast carcinomas (range 4.2-133.6 and 10.7-1862.9 kU/g protein, resp.). The correlation between c-erbB-2 measured by ELISA and detected semiquantitatively by immunohistochemistry was statistically significant. Dysplastic tissues with higher relative risk of malignant transformation were characterized by elevated c-erbB-2 values. In breast cancer patients, c-erbB-2 overexpression was inversely associated with disease-free interval. No correlation was found between c-erbB-2 and grading, lymph node infiltration, tumor size, or hormone receptor status.

Název v anglickém jazyce

Prognostic significance of c-erbB-2 (HER-2/neu) oncoprotein and other parameters in benign and malignant breast tumor tissue

Popis výsledku anglicky

The overexpression of c-erbB-2 (HER2/neu) oncoprotein was analyzed quantitatively by ELISA in tissue extracts of benign and malignant breast tumors (N= 38 and 145, resp.). The level of this oncoprotein was above the cut-off value (100 kU/g protein) in 5%of dysplastic tissues and in 37 % of breast carcinomas (range 4.2-133.6 and 10.7-1862.9 kU/g protein, resp.). The correlation between c-erbB-2 measured by ELISA and detected semiquantitatively by immunohistochemistry was statistically significant. Dysplastic tissues with higher relative risk of malignant transformation were characterized by elevated c-erbB-2 values. In breast cancer patients, c-erbB-2 overexpression was inversely associated with disease-free interval. No correlation was found between c-erbB-2 and grading, lymph node infiltration, tumor size, or hormone receptor status.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

1999

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Tumor Marker Oncology

ISSN

0886-3849

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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