Quantitative analysis of c-erbB-2 oncoprotein in breast tumor tissue

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative analysis of c-erbB-2 oncoprotein in breast tumor tissue

Popis výsledku v původním jazyce

The study was designed to evaluate the prognostic importance of c-erbB-2 overexpression in breast cancer patients. In a retrospective study using breast tissue material we 1) analyzed quantitatively c-erbB-2 oncoprotein in breast cyst fluids of benign fibrocystic disease, in extracts of dysplastic tissues, fibroadenomas, phylloid tumors, and breast cancers, 2) we compared the results of the ELISA quantitative estimation with immunohistochemical localization, 3) we correlated these results with medicalhistory data, with available biochemical examinations, and with preliminary results of telomerase activity determinations as a measure of immortal character of tumor tissue. The c-erbB-2 oncoprotein expression differed significantly in benign and malignantbreast tumors,the highest concentrations were found in the breast cancer group (37% of malignant specimens were higher than cut-off value 100kU/g protein).The levels of this oncoprotein showed the inverse correlation with disease-free in

Název v anglickém jazyce

Quantitative analysis of c-erbB-2 oncoprotein in breast tumor tissue

Popis výsledku anglicky

The study was designed to evaluate the prognostic importance of c-erbB-2 overexpression in breast cancer patients. In a retrospective study using breast tissue material we 1) analyzed quantitatively c-erbB-2 oncoprotein in breast cyst fluids of benign fibrocystic disease, in extracts of dysplastic tissues, fibroadenomas, phylloid tumors, and breast cancers, 2) we compared the results of the ELISA quantitative estimation with immunohistochemical localization, 3) we correlated these results with medicalhistory data, with available biochemical examinations, and with preliminary results of telomerase activity determinations as a measure of immortal character of tumor tissue. The c-erbB-2 oncoprotein expression differed significantly in benign and malignantbreast tumors,the highest concentrations were found in the breast cancer group (37% of malignant specimens were higher than cut-off value 100kU/g protein).The levels of this oncoprotein showed the inverse correlation with disease-free in

Druh

D - Stať ve sborníku

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

1999

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

20th OECI Annual Scientific Meeting associated with 23rd Brno Days of Oncology and 13th Conference of Nurses

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

Masarykův onkologický ústav

Místo vydání

Brno

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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