Breast tumor tissue analysis of the prediction of disease progression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F99%3A00000023" target="_blank" >RIV/00209805:_____/99:00000023 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Breast tumor tissue analysis of the prediction of disease progression

Popis výsledku v původním jazyce

The current status of prognostic factors in primary breast cancer permits an increasingly accurate prediction of prognosis and benefit of therapy. The new possible risk factor of relaps in resectable breast tumor were described recently: selected oncogenand product of their expression, growth factors and its receptors, proteases, factors connected with multidrug resistence, apoptosis, or immortal character of tumors (telomerase). In retrospective study using breast tissue material obtained during 1986 -1996 we analyzed c-erbB-2 oncoprotein tissue concentration in dysplastic tissues, in fibroadenomas, phylloid tumors, and in breast carcinomas and compared the results of the quantitative estimation of this oncoprotein with immunohistochemical loclocalization. In this material we analyzed also CEA, CA 15-3, TPS, and CYFRA 21-1 in tumor cytosol, and telomerase activity in tissue and correlated all results with medical history data and with available histological and biochemical examinatio

Název v anglickém jazyce

Breast tumor tissue analysis of the prediction of disease progression

Popis výsledku anglicky

The current status of prognostic factors in primary breast cancer permits an increasingly accurate prediction of prognosis and benefit of therapy. The new possible risk factor of relaps in resectable breast tumor were described recently: selected oncogenand product of their expression, growth factors and its receptors, proteases, factors connected with multidrug resistence, apoptosis, or immortal character of tumors (telomerase). In retrospective study using breast tissue material obtained during 1986 -1996 we analyzed c-erbB-2 oncoprotein tissue concentration in dysplastic tissues, in fibroadenomas, phylloid tumors, and in breast carcinomas and compared the results of the quantitative estimation of this oncoprotein with immunohistochemical loclocalization. In this material we analyzed also CEA, CA 15-3, TPS, and CYFRA 21-1 in tumor cytosol, and telomerase activity in tissue and correlated all results with medical history data and with available histological and biochemical examinatio

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

1999

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomarkers and Enviroment

ISSN

1211-8869

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

2

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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