Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8838" target="_blank" >RIV/00216208:11110/11:8838 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064211:_____/11:#0000086

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s15010-011-0126-4" target="_blank" >http://dx.doi.org/10.1007/s15010-011-0126-4</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

Popis výsledku v původním jazyce

The goal of this study was to evaluace routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. In this prospective study, 54 adult patients with bacterial infections were included. For comparison, 27 patients with viral infections were enrolled. In these patients, white blood cell (WBC) counts, differential blood counts, serum levels of procalcitonin (PCT), IL-1b, IL-6, IL-8, IL-10, IL-12, TNF-a, IFN-c, soluble CD14 (sCD14), heparinbinding protein (HBP), cortisol (Cort), and monocyte surface expression of TLR2, TLR4, HLA-DR, and CD14 were analyzed. The highest sensitivity and specificity (expressed as the area under the curve [AUC]) for bacterial infection were observed in serum concentration of PCT (0.952), neutrophil and lymphocyte counts (0.852 and 0.841, respectively), and serumlevels of HBP (0.837), IL-6 (0.830), and Cort (0.817). From the novel potential biomarkers, only PCT demonstrated superiority over the routine parameters in the dif

Název v anglickém jazyce

Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

Popis výsledku anglicky

The goal of this study was to evaluace routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. In this prospective study, 54 adult patients with bacterial infections were included. For comparison, 27 patients with viral infections were enrolled. In these patients, white blood cell (WBC) counts, differential blood counts, serum levels of procalcitonin (PCT), IL-1b, IL-6, IL-8, IL-10, IL-12, TNF-a, IFN-c, soluble CD14 (sCD14), heparinbinding protein (HBP), cortisol (Cort), and monocyte surface expression of TLR2, TLR4, HLA-DR, and CD14 were analyzed. The highest sensitivity and specificity (expressed as the area under the curve [AUC]) for bacterial infection were observed in serum concentration of PCT (0.952), neutrophil and lymphocyte counts (0.852 and 0.841, respectively), and serumlevels of HBP (0.837), IL-6 (0.830), and Cort (0.817). From the novel potential biomarkers, only PCT demonstrated superiority over the routine parameters in the dif

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11390" target="_blank" >NT11390: Nové biomarkery pro časnou detekci nozokomiální infekce v intenzivní péči</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection

ISSN

0300-8126

e-ISSN

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Svazek periodika

39

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

411-417

Kód UT WoS článku

000296843100004

EID výsledku v databázi Scopus

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