Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192311" target="_blank" >RIV/00216208:11110/13:10192311 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1158/1940-6207.CAPR-13-0125" target="_blank" >http://dx.doi.org/10.1158/1940-6207.CAPR-13-0125</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1940-6207.CAPR-13-0125" target="_blank" >10.1158/1940-6207.CAPR-13-0125</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

Popis výsledku v původním jazyce

The bile pigment bilirubin is a known antioxidant and is associated with protection from cancer and cardiovascular disease (CVD) when present in too strong concentrations. Unconjugated bilirubin (UCB) might also possess anti-genotoxic potential by preventing oxidative damage to DNA. Moderately elevated bilirubin levels are found in individuals with Gilbert syndrome and more severe in the hyperbilirubinemic Gunn rat model. This study was therefore aimed to assess the levels of oxidative damage to DNA inGilbert syndrome subjects and Gunn rats compared tomatched controls. Seventy-six individuals (age- and sex-matched) were allocated into Gilbert syndrome (UCB }= 17.1 mu mol/L; n - 38) or control groups (UCB < 17.1 mu mol/L; n = 38). In addition, 40 Gunnrats were used to support the results of the human trial. Single-cell gel electrophoresis (SCGE) assay measuring standard conditions (strand breaks, apurinic/apyrimidinic sites) and formamidopyrimidine glycosylase (FPG)-sensitive sites wa

Název v anglickém jazyce

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

Popis výsledku anglicky

The bile pigment bilirubin is a known antioxidant and is associated with protection from cancer and cardiovascular disease (CVD) when present in too strong concentrations. Unconjugated bilirubin (UCB) might also possess anti-genotoxic potential by preventing oxidative damage to DNA. Moderately elevated bilirubin levels are found in individuals with Gilbert syndrome and more severe in the hyperbilirubinemic Gunn rat model. This study was therefore aimed to assess the levels of oxidative damage to DNA inGilbert syndrome subjects and Gunn rats compared tomatched controls. Seventy-six individuals (age- and sex-matched) were allocated into Gilbert syndrome (UCB }= 17.1 mu mol/L; n - 38) or control groups (UCB < 17.1 mu mol/L; n = 38). In addition, 40 Gunnrats were used to support the results of the human trial. Single-cell gel electrophoresis (SCGE) assay measuring standard conditions (strand breaks, apurinic/apyrimidinic sites) and formamidopyrimidine glycosylase (FPG)-sensitive sites wa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Prevention Research

ISSN

1940-6207

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1056-1063

Kód UT WoS článku

000325272400007

EID výsledku v databázi Scopus

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