Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10312820" target="_blank" >RIV/00216208:11110/15:10312820 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10312820

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360800/pdf/NEURIMMINFL2014003087.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360800/pdf/NEURIMMINFL2014003087.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1212/NXI.0000000000000081" target="_blank" >10.1212/NXI.0000000000000081</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children

Popis výsledku v původním jazyce

Objective: To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). Method: Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France. Acute serum samples were tested for MOG-Abs by cell-based assay. Antibodies were used to predict diagnosis of multiple sclerosis (MS) at 1 year. Results: Twenty-three of 65 (35%) children had MOG-Abs. Antibody-positive and antibodynegative patients were not clinically different at presentation, but identification of MOG-Abs predicted a non-MS course at 1-year follow-up: only 2/23 (9%) MOG-Ab-positive patients were diagnosed with MS compared to 16/42 (38%) MOG-Ab-negative patients (p 5 0.019, Fisher exact test). Antibody posi

Název v anglickém jazyce

Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children

Popis výsledku anglicky

Objective: To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). Method: Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France. Acute serum samples were tested for MOG-Abs by cell-based assay. Antibodies were used to predict diagnosis of multiple sclerosis (MS) at 1 year. Results: Twenty-three of 65 (35%) children had MOG-Abs. Antibody-positive and antibodynegative patients were not clinically different at presentation, but identification of MOG-Abs predicted a non-MS course at 1-year follow-up: only 2/23 (9%) MOG-Ab-positive patients were diagnosed with MS compared to 16/42 (38%) MOG-Ab-negative patients (p 5 0.019, Fisher exact test). Antibody posi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13239" target="_blank" >NT13239: Fenotypizace axonálního postižení u RS na základě in vivo měření retinální patologie pomocí OCT</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurology: Neuroimmunology &amp; Neuroinflammation

ISSN

2332-7812

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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