The comparison of selected cerebrospinal fluid and serum cytokine levels in patients with multiple sclerosis and normal pressure hydrocephalus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10320164" target="_blank" >RIV/00216208:11110/15:10320164 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/15:#0000537 RIV/00064165:_____/15:10320164

Výsledek na webu

<a href="http://www.nel.edu/archive_issues/o/36_6/36_6_Sosvorova_564-571.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/36_6/36_6_Sosvorova_564-571.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The comparison of selected cerebrospinal fluid and serum cytokine levels in patients with multiple sclerosis and normal pressure hydrocephalus

Popis výsledku v původním jazyce

OBJECTIVES: Cytokine production and immune activation are associated with various pathological conditions including neurodegenerative disorders. One of them is multiple sclerosis (MS), known autoimmune disease. Inflammatory changes were also reported innormal pressure hydrocephalus (NPH), neurodegenerative disorder, which pathophysiology remains still unclear. The aim of this research was to compare the group of MS subjects with NPH patients and controls and to evaluate the potential inflammatory substance of NPH in comparison with autoimmune inflamed MS. METHODS: The levels of IL-1 beta, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, INF-gamma, sCD40L and TNF-alpha were measured in cerebrospinal fluid (CSF) and plasma insubjects with MS (n=15), NPH (n=18) and controls (n=11) by multiplex assay. RESULTS: The increased levels of IL-1 beta, IL-6, IL-10, IL-21 and TNF-alpha in cerebrospinal fluid of NPH subjects in comparison with MS patients and controls w

Název v anglickém jazyce

The comparison of selected cerebrospinal fluid and serum cytokine levels in patients with multiple sclerosis and normal pressure hydrocephalus

Popis výsledku anglicky

OBJECTIVES: Cytokine production and immune activation are associated with various pathological conditions including neurodegenerative disorders. One of them is multiple sclerosis (MS), known autoimmune disease. Inflammatory changes were also reported innormal pressure hydrocephalus (NPH), neurodegenerative disorder, which pathophysiology remains still unclear. The aim of this research was to compare the group of MS subjects with NPH patients and controls and to evaluate the potential inflammatory substance of NPH in comparison with autoimmune inflamed MS. METHODS: The levels of IL-1 beta, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, INF-gamma, sCD40L and TNF-alpha were measured in cerebrospinal fluid (CSF) and plasma insubjects with MS (n=15), NPH (n=18) and controls (n=11) by multiplex assay. RESULTS: The increased levels of IL-1 beta, IL-6, IL-10, IL-21 and TNF-alpha in cerebrospinal fluid of NPH subjects in comparison with MS patients and controls w

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13814" target="_blank" >NT13814: Úloha neurosteroidů v etiopatogenezi roztroušené sklerózy</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

8

Strana od-do

564-571

Kód UT WoS článku

000369425600009

EID výsledku v databázi Scopus

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