Fecal zonulin is elevated in Crohn's disease and in cigarette smokers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366651" target="_blank" >RIV/00216208:11110/17:10366651 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/17:10366651

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.plabm.2017.09.001" target="_blank" >http://dx.doi.org/10.1016/j.plabm.2017.09.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.plabm.2017.09.001" target="_blank" >10.1016/j.plabm.2017.09.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fecal zonulin is elevated in Crohn's disease and in cigarette smokers

Popis výsledku v původním jazyce

Objectives: Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin&apos;s participation in inflammatory bowel diseases (IBD). The aim of this study was therefore to investigate fecal and serum zonulin in IBD patients and its relation to the disease localization, behavior and smoking status. Design and methods: Forty IBD patients and forty healthy persons were examined for fecal and serum zonulin concentrations by competitive ELISA (DRG International Inc). Values were correlated to IBD type, localization and behavior, and smoking. Results: Serum and fecal zonulin were significantly higher in patients with Crohn&apos;s disease compared to ulcerative colitis (p = 0.038 for fecal zonulin, and p = 0.041 for serum zonulin concentrations). No association of serum or fecal zonulin was found with respect to IBD localization and behavior. The only difference was found with respect to smoking. Both the IBD cohort and healthy smokers showed significantly higher fecal zonulin levels (median 203 ng/mL) compared to non-smokers (median 35.8 ng/mL), p &lt; 0.001. Conclusions: Fecal and serum zonulin levels are elevated in patients with active Crohn&apos;s disease but not with ulcerative colitis. High fecal zonulin levels in smokers irrespective of IBD point to the significant and undesirable up-regulation of gut permeability in cigarette smokers.

Název v anglickém jazyce

Fecal zonulin is elevated in Crohn's disease and in cigarette smokers

Popis výsledku anglicky

Objectives: Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin&apos;s participation in inflammatory bowel diseases (IBD). The aim of this study was therefore to investigate fecal and serum zonulin in IBD patients and its relation to the disease localization, behavior and smoking status. Design and methods: Forty IBD patients and forty healthy persons were examined for fecal and serum zonulin concentrations by competitive ELISA (DRG International Inc). Values were correlated to IBD type, localization and behavior, and smoking. Results: Serum and fecal zonulin were significantly higher in patients with Crohn&apos;s disease compared to ulcerative colitis (p = 0.038 for fecal zonulin, and p = 0.041 for serum zonulin concentrations). No association of serum or fecal zonulin was found with respect to IBD localization and behavior. The only difference was found with respect to smoking. Both the IBD cohort and healthy smokers showed significantly higher fecal zonulin levels (median 203 ng/mL) compared to non-smokers (median 35.8 ng/mL), p &lt; 0.001. Conclusions: Fecal and serum zonulin levels are elevated in patients with active Crohn&apos;s disease but not with ulcerative colitis. High fecal zonulin levels in smokers irrespective of IBD point to the significant and undesirable up-regulation of gut permeability in cigarette smokers.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Practical Laboratory Medicine [online]

ISSN

2352-5517

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

39-44

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85030089146