Severe suicidal self-poisoning with massive dose of potassium ferricyanide(III): hyperkalemia but not free cyanide may cause death

Kód výsledku v IS VaVaI

RIV/00216208:11110/18:10378274 - isvavai.cz

Nalezeny alternativní kódy

RIV/61388955:_____/18:00492509 RIV/00064165:_____/18:10378274

Výsledek na webu

https://doi.org/10.1007/s00706-018-2231-x

DOI - Digital Object Identifier

10.1007/s00706-018-2231-x

Jazyk výsledku

angličtina

Název v původním jazyce

Severe suicidal self-poisoning with massive dose of potassium ferricyanide(III): hyperkalemia but not free cyanide may cause death

Popis výsledku v původním jazyce

Potassium ferricyanide(III), K-3[Fe(CN)(6)], has a widespread use in blueprint drawing, photography, chemical industry, and metallurgy. In mice, the oral lethal dose 50 (LD50) is 1600 mg kg(-1). We report the case of a suicide attempt in a 37-year-old male by intentional ingestion of 80 g of potassium ferricyanide(III) dissolved in water. The estimated ingested dose was 770 mg kg(-1). The patient reported vertigo as the first sign of poisoning and six episodes of diarrhea with dark-colored stool 2 h after ingestion. The patient was transported by ambulance to the intensive care unit 8 h after ingestion. He was conscious and spontaneously ventilating, with a Glasgow Coma Scale (GCS) score of 15. On ECG performed at admission, tall "tented" T waves in V3-V6 and progressive flattering of P waves were registered. Serum concentrations of potassium of 7.2 mmol dm(-3), urea of 7.1 mmol dm(-3), and creatinine of 162 A mu mol dm(-3) indicated development of acute renal failure. Despite the administration of intravenous insulin and 10% glucose infusion during the first hours after admission, there was a further elevation of serum potassium to 7.4 mmol dm(-3) suggesting acute renal failure. For this reason, intermittent hemodialysis was performed [duration 200 min, blood flow rate 147 cm(3) min(-1), online clearance monitoring (OCM) clearance rate 100 cm(3) min(-1), and substitution fluid volume 5.8 dm(3)]. The condition of the patient stabilized and he was discharged from hospital on the fourth day after admission. This case report demonstrates the risks of life-threatening hyperkalemia and acute renal failure as complications of massive ingestion of potassium ferricyanide(III).

Název v anglickém jazyce

Severe suicidal self-poisoning with massive dose of potassium ferricyanide(III): hyperkalemia but not free cyanide may cause death

Popis výsledku anglicky

Potassium ferricyanide(III), K-3[Fe(CN)(6)], has a widespread use in blueprint drawing, photography, chemical industry, and metallurgy. In mice, the oral lethal dose 50 (LD50) is 1600 mg kg(-1). We report the case of a suicide attempt in a 37-year-old male by intentional ingestion of 80 g of potassium ferricyanide(III) dissolved in water. The estimated ingested dose was 770 mg kg(-1). The patient reported vertigo as the first sign of poisoning and six episodes of diarrhea with dark-colored stool 2 h after ingestion. The patient was transported by ambulance to the intensive care unit 8 h after ingestion. He was conscious and spontaneously ventilating, with a Glasgow Coma Scale (GCS) score of 15. On ECG performed at admission, tall "tented" T waves in V3-V6 and progressive flattering of P waves were registered. Serum concentrations of potassium of 7.2 mmol dm(-3), urea of 7.1 mmol dm(-3), and creatinine of 162 A mu mol dm(-3) indicated development of acute renal failure. Despite the administration of intravenous insulin and 10% glucose infusion during the first hours after admission, there was a further elevation of serum potassium to 7.4 mmol dm(-3) suggesting acute renal failure. For this reason, intermittent hemodialysis was performed [duration 200 min, blood flow rate 147 cm(3) min(-1), online clearance monitoring (OCM) clearance rate 100 cm(3) min(-1), and substitution fluid volume 5.8 dm(3)]. The condition of the patient stabilized and he was discharged from hospital on the fourth day after admission. This case report demonstrates the risks of life-threatening hyperkalemia and acute renal failure as complications of massive ingestion of potassium ferricyanide(III).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

—

Svazek periodika

149

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

5

Strana od-do

1647-1651

Kód UT WoS článku

000442501400021

EID výsledku v databázi Scopus

2-s2.0-85051624890