Changes in circulating stem cells and endothelial progenitor cells over a 12-month period after implantation of a continuous-flow left ventricular assist device

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10417776" target="_blank" >RIV/00216208:11110/20:10417776 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/20:43920781 RIV/00216208:11130/20:10417776 RIV/00064203:_____/20:10417776 RIV/00023001:_____/20:00080322

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Mp-AN4zMRV" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Mp-AN4zMRV</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/aoms.2020.100306" target="_blank" >10.5114/aoms.2020.100306</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Changes in circulating stem cells and endothelial progenitor cells over a 12-month period after implantation of a continuous-flow left ventricular assist device

Popis výsledku v původním jazyce

Introduction: Changes in circulating CD34+CD45low stem cells (SC) and CD34+CD45low-FKDR+ endothelial progenitor cells (EPC) may reflect pathological endothelial activation. Non-pulsatile/continuous-flow left ventricular assist devices (CF-LVAD) can enhance this process. The aim of this study was to analyse the impact of 12-month CF-LVAD treatment on SC and EPC. Methods: We analysed changes in SC and EPC from the pre-implantation period up until 12 months after implantation over 3-month intervals in 14 patients. Data from 12 patients with heart failure (HF) and from 13 healthy volunteers were used as controls. Results: Baseline EPC were significantly higher in CF-LVAD and HF patients than in healthy controls, substantially decreasing 3 months after CF-LVAD implantation and then returning to high baseline values at 12 months. Conclusions: Changes in circulating SC and EPC may reflect pathological endothelial activation after CF-LVAD implantation.

Název v anglickém jazyce

Changes in circulating stem cells and endothelial progenitor cells over a 12-month period after implantation of a continuous-flow left ventricular assist device

Popis výsledku anglicky

Introduction: Changes in circulating CD34+CD45low stem cells (SC) and CD34+CD45low-FKDR+ endothelial progenitor cells (EPC) may reflect pathological endothelial activation. Non-pulsatile/continuous-flow left ventricular assist devices (CF-LVAD) can enhance this process. The aim of this study was to analyse the impact of 12-month CF-LVAD treatment on SC and EPC. Methods: We analysed changes in SC and EPC from the pre-implantation period up until 12 months after implantation over 3-month intervals in 14 patients. Data from 12 patients with heart failure (HF) and from 13 healthy volunteers were used as controls. Results: Baseline EPC were significantly higher in CF-LVAD and HF patients than in healthy controls, substantially decreasing 3 months after CF-LVAD implantation and then returning to high baseline values at 12 months. Conclusions: Changes in circulating SC and EPC may reflect pathological endothelial activation after CF-LVAD implantation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV16-27630A" target="_blank" >NV16-27630A: Markery vaskulárního zdraví u pacientů s implantovanou mechanickou srdeční podporou</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Medical Science

ISSN

1734-1922

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

4

Strana od-do

1440-1443

Kód UT WoS článku

000585918400020

EID výsledku v databázi Scopus

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