Biphasic response in number of stem cells and endothelial progenitor cells after left ventricular assist device implantation: A 6 month follow-up

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059988" target="_blank" >RIV/00023001:_____/16:00059988 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10324408 RIV/00216208:11130/16:10324408 RIV/00216208:11120/16:43911610 RIV/00159816:_____/16:00068432

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0167527316309330" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0167527316309330</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2016.05.063" target="_blank" >10.1016/j.ijcard.2016.05.063</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biphasic response in number of stem cells and endothelial progenitor cells after left ventricular assist device implantation: A 6 month follow-up

Popis výsledku v původním jazyce

Background: Continuous blood flow could have deleterious effects on endothelium and vascular health. This could have serious consequences in patients with heart failure treated with continuous flow left ventricular assist devices (LVAD). Therefore, we studied effect of LVAD on three circulating vascular biomarkers: stem cells (SC), endothelial progenitor cells (EPC) and microparticles (MP). Methods: In 23 patients (5 women) with end-stage heart failure, SC, EPC and MP were measured before, and 3 and 6 months after implantation of LVAD (HeartMate II). SC were defined using determination of surface antigen expression as mononuclear CD34+/CD45low+ cells and EPC as mononuclear CD34+/CD45low+/KDR+ cells. MP concentrations were determined by ELISA method. Results: Three months after LVAD implantation numbers of SC and EPC significantly decreased (p = 0.01 and p = 0.001, respectively). On the contrary, between 3rd and 6th month after implantation they significantly increased (p = 0.006 and p = 0.003, respectively). MP did not change significantly during the study despite exerting similar trend as SC and EPC. Conclusions: Observed biphasic changes of SC and EPC might reflect two processes. First, shortly after LVAD implantation, improved tissue perfusion could lead to decrease in ischemic stimuli and ensuing decrease of SC and EPC. Second, continuous flow between 3rd and 6th month produced by LVAD could lead to increase of SC and EPC through activation of endothelium. This explanation could be supported also by similar trend in the changes of concentrations of MP.

Název v anglickém jazyce

Biphasic response in number of stem cells and endothelial progenitor cells after left ventricular assist device implantation: A 6 month follow-up

Popis výsledku anglicky

Background: Continuous blood flow could have deleterious effects on endothelium and vascular health. This could have serious consequences in patients with heart failure treated with continuous flow left ventricular assist devices (LVAD). Therefore, we studied effect of LVAD on three circulating vascular biomarkers: stem cells (SC), endothelial progenitor cells (EPC) and microparticles (MP). Methods: In 23 patients (5 women) with end-stage heart failure, SC, EPC and MP were measured before, and 3 and 6 months after implantation of LVAD (HeartMate II). SC were defined using determination of surface antigen expression as mononuclear CD34+/CD45low+ cells and EPC as mononuclear CD34+/CD45low+/KDR+ cells. MP concentrations were determined by ELISA method. Results: Three months after LVAD implantation numbers of SC and EPC significantly decreased (p = 0.01 and p = 0.001, respectively). On the contrary, between 3rd and 6th month after implantation they significantly increased (p = 0.006 and p = 0.003, respectively). MP did not change significantly during the study despite exerting similar trend as SC and EPC. Conclusions: Observed biphasic changes of SC and EPC might reflect two processes. First, shortly after LVAD implantation, improved tissue perfusion could lead to decrease in ischemic stimuli and ensuing decrease of SC and EPC. Second, continuous flow between 3rd and 6th month produced by LVAD could lead to increase of SC and EPC through activation of endothelium. This explanation could be supported also by similar trend in the changes of concentrations of MP.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14019" target="_blank" >NT14019: Vliv pulsalitilty krevního toku na parametry vaskulárního postižení u pacientů s mechanickou srdeční podporou.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

218

Číslo periodika v rámci svazku

September 2016

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

98-103

Kód UT WoS článku

000377856300017

EID výsledku v databázi Scopus

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