Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F00%3A00003729" target="_blank" >RIV/00216208:11120/00:00003729 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1078/0065-1281-00573" target="_blank" >http://dx.doi.org/10.1078/0065-1281-00573</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1078/0065-1281-00573" target="_blank" >10.1078/0065-1281-00573</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes

Popis výsledku v původním jazyce

n lymph nodes, dendritic cells form a complex meshwork and are linked by intercellular junctions. Intercellular junctions contribute to the integrity of lymphatic follicles and can potentially be affected by malignant processes in neighbouring B cells. We examined whether transmembrane molecules that constitute "adherens junctions" are present in follicular dendritic cells of normal human lymph nodes. We found that follicular dendritic cells but not interdigitating dendritic cells or sinus lining cellsexpressed cadherin molecules. Follicular dendritic cells also expressed beta -catenin but not vinculin. The cadherin molecules, which were identified in situ with the use of a monoclonal pan-cadherin antibody, were not recognized by antibodies to E-cadherin, N-cadherin or beta -cadherin. Intrafollicularly, cadherins were clearly colocalized with beta -catenins, in a dot-like fashion. We also detected intrafollicular expression of desmogleins and desmosomal plaque proteins. These findings

Název v anglickém jazyce

Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes

Popis výsledku anglicky

n lymph nodes, dendritic cells form a complex meshwork and are linked by intercellular junctions. Intercellular junctions contribute to the integrity of lymphatic follicles and can potentially be affected by malignant processes in neighbouring B cells. We examined whether transmembrane molecules that constitute "adherens junctions" are present in follicular dendritic cells of normal human lymph nodes. We found that follicular dendritic cells but not interdigitating dendritic cells or sinus lining cellsexpressed cadherin molecules. Follicular dendritic cells also expressed beta -catenin but not vinculin. The cadherin molecules, which were identified in situ with the use of a monoclonal pan-cadherin antibody, were not recognized by antibodies to E-cadherin, N-cadherin or beta -cadherin. Intrafollicularly, cadherins were clearly colocalized with beta -catenins, in a dot-like fashion. We also detected intrafollicular expression of desmogleins and desmosomal plaque proteins. These findings

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/VS96129" target="_blank" >VS96129: Laboratoř genové exprese</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Histochemica

ISSN

0065-1281

e-ISSN

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Svazek periodika

102

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

16

Strana od-do

369-380

Kód UT WoS článku

000165865000001

EID výsledku v databázi Scopus

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