Correlation of histological grade and expression of adhesion molecules in canine mammary gland carcinomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F24%3A43881356" target="_blank" >RIV/62157124:16170/24:43881356 - isvavai.cz</a>

Výsledek na webu

<a href="http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://actavet.vfu.cz/media/pdf/actavet_2024093010011.pdf" target="_blank" >http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://actavet.vfu.cz/media/pdf/actavet_2024093010011.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb202493010011" target="_blank" >10.2754/avb202493010011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Correlation of histological grade and expression of adhesion molecules in canine mammary gland carcinomas

Popis výsledku v původním jazyce

The histological grade is usually used as a prognostic factor in canine mammary gland carcinomas, but the actual biological behaviour is not always in accordance with this available tool. Disrupted expression of cell adhesion molecules is a very promising way how to predict possible tumour spread. The goal of this study was to detect and quantify the expression of adhesion molecule E-cadherin and beta-catenin by means of immunofluorescence and relate the findings with the histological grade in 18 samples of canine mammary gland carcinomas. There is a disruption of beta-catenin and E-cadherin expression in canine mammary carcinoma. Significantly positive correlation was found between the expression index of E-cadherin and beta-catenin with the histological grade. A significant difference (P &lt; 0.05) in the membrane index (MI) of beta-catenin expression was found between groups of canine mammary carcinomas (CMCs) grade I and II, grade I and III, grade II and III. A significant difference (P &lt; 0.05) in the MI of E-cadherin expression was also found between groups of CMCs grade I and II, grade I and III, grade II and III. A significant difference (P &lt; 0.05) in the cytoplasmic index (CI) of beta-catenin expression was found between groups of CMCs grade I and II, grade I and III. In the case of CI expression of E-cadherin, no significant difference was found in the expression of E-cadherinin CMCs of different grade. The results of the study show that these adhesion molecules could be promising markers in determining the prognosis of patients with CMCs.

Název v anglickém jazyce

Correlation of histological grade and expression of adhesion molecules in canine mammary gland carcinomas

Popis výsledku anglicky

The histological grade is usually used as a prognostic factor in canine mammary gland carcinomas, but the actual biological behaviour is not always in accordance with this available tool. Disrupted expression of cell adhesion molecules is a very promising way how to predict possible tumour spread. The goal of this study was to detect and quantify the expression of adhesion molecule E-cadherin and beta-catenin by means of immunofluorescence and relate the findings with the histological grade in 18 samples of canine mammary gland carcinomas. There is a disruption of beta-catenin and E-cadherin expression in canine mammary carcinoma. Significantly positive correlation was found between the expression index of E-cadherin and beta-catenin with the histological grade. A significant difference (P &lt; 0.05) in the membrane index (MI) of beta-catenin expression was found between groups of canine mammary carcinomas (CMCs) grade I and II, grade I and III, grade II and III. A significant difference (P &lt; 0.05) in the MI of E-cadherin expression was also found between groups of CMCs grade I and II, grade I and III, grade II and III. A significant difference (P &lt; 0.05) in the cytoplasmic index (CI) of beta-catenin expression was found between groups of CMCs grade I and II, grade I and III. In the case of CI expression of E-cadherin, no significant difference was found in the expression of E-cadherinin CMCs of different grade. The results of the study show that these adhesion molecules could be promising markers in determining the prognosis of patients with CMCs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

1801-7576

Svazek periodika

93

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

001199853700011

EID výsledku v databázi Scopus

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