Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43899314" target="_blank" >RIV/00216208:11120/12:43899314 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/12:43913798

Výsledek na webu

<a href="http://dx.doi.org/10.1503/jpn.110143" target="_blank" >http://dx.doi.org/10.1503/jpn.110143</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1503/jpn.110143" target="_blank" >10.1503/jpn.110143</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

Popis výsledku v původním jazyce

Smaller hippocampal volumes relative to controls are among the most replicated neuroimaging findings in individuals with unipolar but not bipolar depression. Preserved hippocampal volumes in most studies of participants with bipolar disorder may reflectpotential neuroprotective effects of lithium (Li). Methods: To investigate hippocampal volumes in patients with bipolar disorder while controlling for Li exposure, we performed a meta-analysis of neuroimaging studies that subdivided patients based on thepresence or absence of current Li treatment. To achieve the best coverage of literature, we categorized studies based on whether all or a majority, or whether no or a minority of patients were treated with Li. Hippocampal volumes were compared by combining standardized differences between means (Cohen d) from individual studies using random-effects models. Conclusion: When expos ure to Li was minimized, patients with bipolar disorder showed smaller hippocampal volumes than controls or L

Název v anglickém jazyce

Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

Popis výsledku anglicky

Smaller hippocampal volumes relative to controls are among the most replicated neuroimaging findings in individuals with unipolar but not bipolar depression. Preserved hippocampal volumes in most studies of participants with bipolar disorder may reflectpotential neuroprotective effects of lithium (Li). Methods: To investigate hippocampal volumes in patients with bipolar disorder while controlling for Li exposure, we performed a meta-analysis of neuroimaging studies that subdivided patients based on thepresence or absence of current Li treatment. To achieve the best coverage of literature, we categorized studies based on whether all or a majority, or whether no or a minority of patients were treated with Li. Hippocampal volumes were compared by combining standardized differences between means (Cohen d) from individual studies using random-effects models. Conclusion: When expos ure to Li was minimized, patients with bipolar disorder showed smaller hippocampal volumes than controls or L

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Psychiatry & Neuroscience

ISSN

1180-4882

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

11

Strana od-do

333-343

Kód UT WoS článku

000309209800007

EID výsledku v databázi Scopus

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