Synthetic osmotic dilators for cervical preparation prior to abortion: An international multicentre observational study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43917168" target="_blank" >RIV/00216208:11120/18:43917168 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023698:_____/18:N0000009

Výsledek na webu

<a href="https://doi.org/10.1016/j.ejogrb.2018.07.013" target="_blank" >https://doi.org/10.1016/j.ejogrb.2018.07.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejogrb.2018.07.013" target="_blank" >10.1016/j.ejogrb.2018.07.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthetic osmotic dilators for cervical preparation prior to abortion: An international multicentre observational study

Popis výsledku v původním jazyce

Objectives: To evaluate the outcomes with the use of Dilapan-S for cervical preparation prior to medical or surgical abortion. Study design: International, multicentre, prospective observational study in women between 6 + 0-24 + 0 weeks&apos; gestation. The study was conducted across 7 study sites in 4 countries, between 1/5/2015 to 31/12/2016. The primary outcomes studied were the number of dilators used and the duration required for cervical preparation prior to abortion. Secondary outcomes were complications of dilator use and infection. Participants were followed-up for 4 weeks post procedure to capture any delayed complications. Results: A total of 483 women were enrolled with 439 women eligible for analysis. Medical abortion was performed in 38% (n = 165) women and surgical abortion in 62% (n = 274). For medical abortions and surgical abortions, an average of 3 osmotic dilators for time interval of 4-7 hours provided effective cervical preparation. Medical abortions were performed as day-case procedures (&lt;12 h) in 81% of women. There was no difference in using either adjunctive misoprostol or Dilapan-S followed by misoprostol for cervical ripening effect to achieve complete medical abortion. Dilapan-S permitted surgical abortions to be performed as same-day procedures (&lt;12 h), in 85% of women regardless of gestational age and without the need to use adjunctive or additional misoprostol. There were no serious adverse events reported with the use of Dilapan-S, including in women with a previous caesarean section. The overall infectious morbidity was 0.9% of cases with no causal relationship with the use of synthetic osmotic dilator use (fora length &lt;24 h). In addition, Dilapan-S was reported as easy to insert and remove in over 90% of women. Conclusion: Dilapan-S is a safe and effective method for cervical preparation for medical and surgical abortions up to 24 weeks&apos; gestation. It allows medical and surgical abortions to be performed as day case procedures and is associated with a low complication rate. Future research should aim at directly comparing Dilapan-S and preferred pharmacological agents in a randomised controlled trial.

Název v anglickém jazyce

Synthetic osmotic dilators for cervical preparation prior to abortion: An international multicentre observational study

Popis výsledku anglicky

Objectives: To evaluate the outcomes with the use of Dilapan-S for cervical preparation prior to medical or surgical abortion. Study design: International, multicentre, prospective observational study in women between 6 + 0-24 + 0 weeks&apos; gestation. The study was conducted across 7 study sites in 4 countries, between 1/5/2015 to 31/12/2016. The primary outcomes studied were the number of dilators used and the duration required for cervical preparation prior to abortion. Secondary outcomes were complications of dilator use and infection. Participants were followed-up for 4 weeks post procedure to capture any delayed complications. Results: A total of 483 women were enrolled with 439 women eligible for analysis. Medical abortion was performed in 38% (n = 165) women and surgical abortion in 62% (n = 274). For medical abortions and surgical abortions, an average of 3 osmotic dilators for time interval of 4-7 hours provided effective cervical preparation. Medical abortions were performed as day-case procedures (&lt;12 h) in 81% of women. There was no difference in using either adjunctive misoprostol or Dilapan-S followed by misoprostol for cervical ripening effect to achieve complete medical abortion. Dilapan-S permitted surgical abortions to be performed as same-day procedures (&lt;12 h), in 85% of women regardless of gestational age and without the need to use adjunctive or additional misoprostol. There were no serious adverse events reported with the use of Dilapan-S, including in women with a previous caesarean section. The overall infectious morbidity was 0.9% of cases with no causal relationship with the use of synthetic osmotic dilator use (fora length &lt;24 h). In addition, Dilapan-S was reported as easy to insert and remove in over 90% of women. Conclusion: Dilapan-S is a safe and effective method for cervical preparation for medical and surgical abortions up to 24 weeks&apos; gestation. It allows medical and surgical abortions to be performed as day case procedures and is associated with a low complication rate. Future research should aim at directly comparing Dilapan-S and preferred pharmacological agents in a randomised controlled trial.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Obstetrics &amp; Gynecology and Reproductive Biology

ISSN

0301-2115

e-ISSN

—

Svazek periodika

228

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

249-254

Kód UT WoS článku

000445991800042

EID výsledku v databázi Scopus

2-s2.0-85050155943