MR spectroscopy findings of the basal ganglia in bipolar disorders: A systematic review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43917431" target="_blank" >RIV/00216208:11120/18:43917431 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.2174/2211556007666180621143516" target="_blank" >https://doi.org/10.2174/2211556007666180621143516</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/2211556007666180621143516" target="_blank" >10.2174/2211556007666180621143516</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MR spectroscopy findings of the basal ganglia in bipolar disorders: A systematic review

Popis výsledku v původním jazyce

Objective: Magnetic Resonance Spectroscopy (MRS) is a noninvasive in vivo technique extensively applied to assess the levels of neural metabolites in the brain. We aimed to summarize the findings of proton spectroscopy (1 H MRS) studies addressing neuro-metabolite findings in the Basal Ganglia (BG) of patients with Bipolar Disorders (BD). Method: A search of PubMed and Ovid databases was conducted to identify ¹H MRS studies since 1990 reporting N-acetylaspartate (NAA), phosphocholine plus glycerophosphocholine (PC+GPC), and creatine plus phosphocreatine (Cr+PCr) levels in the BG of patients with BD. Results: Ten original studies were included in this review. Three studies involved BD patients with depressed mood, six studied euthymic BD patients, and one study looked at manic subjects. In depressed BD patients, three studies reported elevated PC+GPC and Cr+PCr levels in the caudate and putamen. NAA levels were found to be elevated in two of the studies, while one reported no change. In euthymic BD patients, five studies reported no group differences with respect to any metabolites, and one study found differences in PC+GPC/Cr+PCr associated with lithium treatment. In mania, lower PC+GPC, lower NAA levels, and increased Cr+PCr levels were described in the caudate of BD patients compared to HC. Conclusion: This review suggests that abnormalities in NAA, GPC+PC, and Cr+PCr levels in the BG might be associated with mood state among BD patients. In addition, the methodological issues involved in the heterogeneity of 1 H MRS findings in BD, as well as the potential role of 1 H MRS findings as biomarkers for BD, are discussed.

Název v anglickém jazyce

MR spectroscopy findings of the basal ganglia in bipolar disorders: A systematic review

Popis výsledku anglicky

Objective: Magnetic Resonance Spectroscopy (MRS) is a noninvasive in vivo technique extensively applied to assess the levels of neural metabolites in the brain. We aimed to summarize the findings of proton spectroscopy (1 H MRS) studies addressing neuro-metabolite findings in the Basal Ganglia (BG) of patients with Bipolar Disorders (BD). Method: A search of PubMed and Ovid databases was conducted to identify ¹H MRS studies since 1990 reporting N-acetylaspartate (NAA), phosphocholine plus glycerophosphocholine (PC+GPC), and creatine plus phosphocreatine (Cr+PCr) levels in the BG of patients with BD. Results: Ten original studies were included in this review. Three studies involved BD patients with depressed mood, six studied euthymic BD patients, and one study looked at manic subjects. In depressed BD patients, three studies reported elevated PC+GPC and Cr+PCr levels in the caudate and putamen. NAA levels were found to be elevated in two of the studies, while one reported no change. In euthymic BD patients, five studies reported no group differences with respect to any metabolites, and one study found differences in PC+GPC/Cr+PCr associated with lithium treatment. In mania, lower PC+GPC, lower NAA levels, and increased Cr+PCr levels were described in the caudate of BD patients compared to HC. Conclusion: This review suggests that abnormalities in NAA, GPC+PC, and Cr+PCr levels in the BG might be associated with mood state among BD patients. In addition, the methodological issues involved in the heterogeneity of 1 H MRS findings in BD, as well as the potential role of 1 H MRS findings as biomarkers for BD, are discussed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Psychiatry Reviews

ISSN

1573-4005

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

99-104

Kód UT WoS článku

000451408600004

EID výsledku v databázi Scopus

2-s2.0-85057572868