No Prognostic Impact of the WT1 Gene Single Nucleotide Polymorphism rs16754 in Pediatric Acute Myeloid Leukemia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F10%3A10209997" target="_blank" >RIV/00216208:11130/10:10209997 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064203:_____/10:10209997
Výsledek na webu
<a href="http://dx.doi.org/10.1200/JCO.2010.29.3860" target="_blank" >http://dx.doi.org/10.1200/JCO.2010.29.3860</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1200/JCO.2010.29.3860" target="_blank" >10.1200/JCO.2010.29.3860</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
No Prognostic Impact of the WT1 Gene Single Nucleotide Polymorphism rs16754 in Pediatric Acute Myeloid Leukemia
Popis výsledku v původním jazyce
We have previously reported the poor prognostic impact of WT1 mutations in a large series of pediatric patients with AML, both in the entire group of patients as well as in those with CN-AML. Moreover, we identified a group with poor prognostics, characterized by the combined presence of a WT1 mutation and an FLT3-ITD. We also described the presence of SNP rs16754, which was distributed equally between WT1-mutated and WT1 wild-type samples, but we did not report its association with outcome. Furthermore, only a few samples were analyzed for WT1 mRNA expression in our series. Primed by the paper from Damm et al, we have now performed a full analysis of the characteristics and prognostic impact of WT1 SNP rs16754 and WT1 mRNA expression in pediatric AML.
Název v anglickém jazyce
No Prognostic Impact of the WT1 Gene Single Nucleotide Polymorphism rs16754 in Pediatric Acute Myeloid Leukemia
Popis výsledku anglicky
We have previously reported the poor prognostic impact of WT1 mutations in a large series of pediatric patients with AML, both in the entire group of patients as well as in those with CN-AML. Moreover, we identified a group with poor prognostics, characterized by the combined presence of a WT1 mutation and an FLT3-ITD. We also described the presence of SNP rs16754, which was distributed equally between WT1-mutated and WT1 wild-type samples, but we did not report its association with outcome. Furthermore, only a few samples were analyzed for WT1 mRNA expression in our series. Primed by the paper from Damm et al, we have now performed a full analysis of the characteristics and prognostic impact of WT1 SNP rs16754 and WT1 mRNA expression in pediatric AML.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2010
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Clinical Oncology
ISSN
0732-183X
e-ISSN
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Svazek periodika
28
Číslo periodika v rámci svazku
28
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
4
Strana od-do
"E523"-"E526"
Kód UT WoS článku
000282272700014
EID výsledku v databázi Scopus
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