Lipophilic fluorescent products of free radicals
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10293071" target="_blank" >RIV/00216208:11130/14:10293071 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/14:00439228
Výsledek na webu
<a href="http://dx.doi.org/10.5507/bp.2012.112" target="_blank" >http://dx.doi.org/10.5507/bp.2012.112</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2012.112" target="_blank" >10.5507/bp.2012.112</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Lipophilic fluorescent products of free radicals
Popis výsledku v původním jazyce
Background. Fluorescent pigments are the end-products of reactions involving free radical attack on biological molecules and can be formed, for example, in reactions between lipid peroxidation products, mainly unsaturated aldehydes, with free amino groups. Their characteristic emission maximum was found to be at 420-470 nm after being excited at 340-390 nm. The mechanism of their formation and chemical identity has been revealed in many in vitro studies, in which reactive aldehydes were incubated with amino group-containing molecules. Owing to their intrinsic fluorescent properties and molecular stability these products are easily measured by means of spectrofluorimetry and are used as biomarkers of oxidative stress caused by various triggers. It has been found that the fluorescent products are formed in excess in conditions linked with increased free radical production, such as atherosclerosis, Alzheimer's disease and multiple sclerosis. Methods. We searched the literature using "MEDL
Název v anglickém jazyce
Lipophilic fluorescent products of free radicals
Popis výsledku anglicky
Background. Fluorescent pigments are the end-products of reactions involving free radical attack on biological molecules and can be formed, for example, in reactions between lipid peroxidation products, mainly unsaturated aldehydes, with free amino groups. Their characteristic emission maximum was found to be at 420-470 nm after being excited at 340-390 nm. The mechanism of their formation and chemical identity has been revealed in many in vitro studies, in which reactive aldehydes were incubated with amino group-containing molecules. Owing to their intrinsic fluorescent properties and molecular stability these products are easily measured by means of spectrofluorimetry and are used as biomarkers of oxidative stress caused by various triggers. It has been found that the fluorescent products are formed in excess in conditions linked with increased free radical production, such as atherosclerosis, Alzheimer's disease and multiple sclerosis. Methods. We searched the literature using "MEDL
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP303%2F11%2F0298" target="_blank" >GAP303/11/0298: Biochemické a morfologické aspekty časného postnatálního vývoje srdce a mozku. Úloha volných radikálů.</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Svazek periodika
158
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
365-372
Kód UT WoS článku
000345398500006
EID výsledku v databázi Scopus
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