Effects of Increased Myocardial Tissue Concentration of Myristic, Palmitic and Palmitoleic Acids on the Course of Cardiac atrophy of the Failing Heart Unloaded by Heterotopic Transplantation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375355" target="_blank" >RIV/00216208:11130/18:10375355 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/18:00076569

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/67/67_13.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/67/67_13.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of Increased Myocardial Tissue Concentration of Myristic, Palmitic and Palmitoleic Acids on the Course of Cardiac atrophy of the Failing Heart Unloaded by Heterotopic Transplantation

Popis výsledku v původním jazyce

The present experiments were performed to evaluate if increased heart tissue concentration of fatty acids, specifically myristic, palmitic and palmitoleic acids that are believed to promote physiological heart growth, can attenuate the progression of unloading-induced cardiac atrophy in rats with healthy and failing hearts. Heterotopic abdominal heart transplantation (HTx) was used as a model for heart unloading. Cardiac atrophy was assessed from the ratio of the native-to-transplanted heart weight (HW). The degree of cardiac atrophy after HTx was determined on days 7, 14, 21 and 28 after HTx in recipients of either healthy or failing hearts. HTx of healthy hearts resulted in 23 +/- 3, 46 +/- 3, 48 +/- 4 and 46 +/- 4 % HW loss at the four time-points. HTx of the failing heart resulted in even greater HW losses, of 46 +/- 4, 58 +/- 3, 66 +/- 2 and 68 +/- 4 %, respectively (P &lt; 0.05). Activation of &quot;fetal gene cardiac program&quot; (e.g. beta myosin heavy chain gene expression) and &quot;genes reflecting cardiac remodeling&quot; (e.g. atrial natriuretic peptide gene expression) after HTx was greater in failing than in healthy hearts (P &lt; 0.05 each time). Exposure to isocaloric high sugar diet caused significant increases in fatty acid concentrations in healthy and in failing hearts. However, these increases were not associated with any change in the course of cardiac atrophy, similarly in healthy and post-HTx failing hearts. We conclude that increasing heart tissue concentrations of the fatty acids allegedly involved in heart growth does not attenuate the unloading-induced cardiac atrophy.

Název v anglickém jazyce

Effects of Increased Myocardial Tissue Concentration of Myristic, Palmitic and Palmitoleic Acids on the Course of Cardiac atrophy of the Failing Heart Unloaded by Heterotopic Transplantation

Popis výsledku anglicky

The present experiments were performed to evaluate if increased heart tissue concentration of fatty acids, specifically myristic, palmitic and palmitoleic acids that are believed to promote physiological heart growth, can attenuate the progression of unloading-induced cardiac atrophy in rats with healthy and failing hearts. Heterotopic abdominal heart transplantation (HTx) was used as a model for heart unloading. Cardiac atrophy was assessed from the ratio of the native-to-transplanted heart weight (HW). The degree of cardiac atrophy after HTx was determined on days 7, 14, 21 and 28 after HTx in recipients of either healthy or failing hearts. HTx of healthy hearts resulted in 23 +/- 3, 46 +/- 3, 48 +/- 4 and 46 +/- 4 % HW loss at the four time-points. HTx of the failing heart resulted in even greater HW losses, of 46 +/- 4, 58 +/- 3, 66 +/- 2 and 68 +/- 4 %, respectively (P &lt; 0.05). Activation of &quot;fetal gene cardiac program&quot; (e.g. beta myosin heavy chain gene expression) and &quot;genes reflecting cardiac remodeling&quot; (e.g. atrial natriuretic peptide gene expression) after HTx was greater in failing than in healthy hearts (P &lt; 0.05 each time). Exposure to isocaloric high sugar diet caused significant increases in fatty acid concentrations in healthy and in failing hearts. However, these increases were not associated with any change in the course of cardiac atrophy, similarly in healthy and post-HTx failing hearts. We conclude that increasing heart tissue concentrations of the fatty acids allegedly involved in heart growth does not attenuate the unloading-induced cardiac atrophy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/NV16-27420A" target="_blank" >NV16-27420A: Přístupy k zabránění rozvoje srdeční atrofie po implantaci levostranné srdeční podpory: studie na potkaním modelu heterotopické transplantace srdce</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

67

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

18

Strana od-do

13-30

Kód UT WoS článku

000426589900002

EID výsledku v databázi Scopus

2-s2.0-85042783108